liposomal Glycine-Iron 80% is a high-purity, liposomal-encapsulated form of ferrous bisglycinate—a fully chelated iron complex in which each ferrous iron ion (Fe²⁺) is bound to two glycine molecules, forming a stable, neutral double-amino acid chelate ring structure. This chelated structure protects iron from dietary inhibitors and is absorbed intact through peptide transport pathways on enterocytes, bypassing the pH-dependent DMT1 pathway used by conventional iron salts. Liposomal encapsulation within a phospholipid bilayer further shields the iron-glycine chelate from gastric acid and food inhibitors, minimizes gastrointestinal irritation, and enables lymphatic absorption for rapid, efficient systemic delivery. This water-dispersible powder is standardized to ≥80% ferrous bisglycinate content, exhibits a light to dark greenish powder appearance, and is suitable for capsules, functional beverages, and nutritional formulations targeting iron deficiency anemia, hemoglobin formation, and Energy Metabolism. Each batch is HPLC-standardized and quality-tested for purity, identity, and elemental iron content.

Product Detailed Description

Liposomal Glycine-Iron 80% — High Bioavailability Chelated Iron Supplement

Product Overview

Liposomal Glycine-Iron 80% is a premium-grade dietary supplement ingredient delivering ferrous bisglycinate in an advanced liposomal delivery system. Ferrous bisglycinate, also known as iron bisglycinate or ferrous glycinate, is a fully reacted amino acid chelate in which a central ferrous iron ion is covalently bonded to the alpha-amino and carboxylate groups of two glycine molecules. This chelation process results in the formation of two stable, five-membered heterocyclic rings—a structural feature fundamental to its enhanced bioavailability and tolerability.

Iron is an essential mineral required for hemoglobin synthesis, oxygen transport, electron transfer, and numerous enzymatic reactions. Conventional iron supplements—particularly ferrous sulfate and ferrous fumarate—exhibit poor bioavailability and frequently cause gastrointestinal side effects including nausea, cramping, constipation, and dark stools. Ferrous bisglycinate addresses these limitations through its chelated structure and dual absorption pathway, while liposomal encapsulation provides an additional layer of protection and delivery enhancement.

Why Liposomal Technology?

Ferrous bisglycinate already offers superior bioavailability and gastrointestinal tolerance compared to conventional iron salts. A systematic review and meta-analysis of 17 randomized controlled trials demonstrated that ferrous bisglycinate supplementation resulted in higher hemoglobin concentrations in pregnant women compared with other iron supplements and significantly fewer gastrointestinal adverse events.

Liposomal encapsulation further enhances its performance through a biomimetic phospholipid bilayer that protects the iron-chelate complex during digestive transit and facilitates efficient cellular delivery.

Liposomal encapsulation provides three critical advantages:

1. Gastric Protection — The phospholipid bilayer shields the iron-glycine chelate from gastric acid degradation and interaction with dietary inhibitors including phytates, tannins, and calcium, preserving its intact structure until reaching optimal absorption sites in the small intestine.

2. Enhanced Absorption via Lymphatic Pathway — Liposomal iron utilizes endocytosis to enter cells directly, bypassing the DMT1 absorption ceiling entirely. liposomes also utilize a lymphatic absorption route, allowing rapid, efficient results. The lipid bilayer protects against acid and food inhibitors, with bioavailability 3 to 5 times higher than ordinary iron.

3. Zero Gut Contact — Minimized Side Effects — Liposomal encapsulation minimizes direct contact between iron and the gastrointestinal mucosa, preventing the Fenton reaction that generates free radicals and causes nausea, cramping, and constipation. The liposomal formulation achieves a high encapsulation efficiency of 87.42% and a loading capacity of 71%.

Product Specifications

Key Features

• High Purity — Standardized to ≥80% ferrous bisglycinate by HPLC, ensuring consistent active content and ≥20% elemental iron.

• Fully Chelated Structure — Each ferrous iron ion is bound to two glycine molecules, creating a stable ring-like chelate structure that protects iron from dietary inhibitors.

• Dual Absorption Pathway — Absorbed intact through peptide transporters on enterocytes, bypassing the pH-dependent DMT1 pathway used by ionic iron salts.

• Superior Bioavailability — Studies demonstrate 2–4 times greater absorption compared to ferrous sulfate on a milligram-for-milligram basis.

• Liposomal Enhancement — Phospholipid bilayer encapsulation achieves 87.42% encapsulation efficiency, 153.8 nm particle size, and −61.22 mV zeta potential, delivering 3–5 times higher absorption than conventional iron.

• Gentle on Digestion — Because iron remains chelated through the gastric environment, it does not generate free ferrous ions that catalyze Fenton reactions and cause nausea, cramping, and constipation.

• Water-Dispersible — Suitable for capsules, tablets, powder drink mixes, and functional beverages.

• Batch Traceability — Complete COA, HPLC chromatogram, FTIR identity confirmation, and elemental iron assay data provided for each batch.

Application & Formulation Guidance

Recommended Dosage

Clinical studies and commercial products commonly recommend 25–75 mg of elemental iron per day for maintenance in healthy adults and 100–200 mg per day for iron deficiency. A typical dosing regimen of 1–2 capsules daily provides approximately 25–50 mg elemental iron per serving. Ferrous bisglycinate can be taken with meals without the typical reduction in absorption seen with ionic iron forms, offering greater flexibility in dosing. Co-supplementation with vitamin C further enhances absorption. Iron status should be monitored through ferritin and transferrin saturation to guide dosing.

Shipping & Lead Time

• Stock Orders: 3–5 business days after payment confirmation.

• Bulk / Custom Orders: 2–3 weeks, depending on quantity and customization requirements.

• Shipping Methods: International Express (FedEx, DHL, UPS), air freight, and sea freight.

• Coverage: Worldwide shipping, including remote areas.