69$/KG
liposomal Magnesium Glycinate 80% is a premium-grade dietary supplement ingredient delivering magnesium bisglycinate in an advanced liposomal delivery system. Magnesium glycinate, also known as magnesium bisglycinate, is a fully chelated mineral complex in which each magnesium molecule is bound to two glycine molecules through a proprietary chelation process. This structure transforms magnesium into an amino acid chelate that the body recognizes as a protein building block rather than an inorganic salt.
Magnesium is an essential mineral required for more than 600 enzymatic reactions throughout the body, contributing to protein synthesis, energy production, normal muscle and nerve function, blood glucose regulation, blood pressure regulation, and the movement of calcium and potassium across cell membranes. However, conventional magnesium supplements—particularly magnesium oxide—exhibit low bioavailability (4–23%) and frequently cause gastrointestinal discomfort. Magnesium glycinate addresses these limitations through its chelated structure and dipeptide transport pathway absorption, while liposomal encapsulation provides an additional layer of protection and delivery enhancement.
Magnesium glycinate already offers superior bioavailability and gastrointestinal tolerance compared to inorganic magnesium salts. Research demonstrates that magnesium bisglycinate has been shown in lab testing to have up to 2.5× better absorption than a leading form, and a clinical trial in patients with ileal resection found that magnesium absorption was substantially greater from the chelate (23.5% vs 11.8% for MgO) in patients with impaired absorption.
Liposomal encapsulation further enhances its performance through a biomimetic phospholipid bilayer that protects the mineral-chelate complex during digestive transit and facilitates efficient cellular delivery.
Liposomal encapsulation provides three critical advantages:
1. Digestive Protection — The phospholipid bilayer shields the magnesium-glycine chelate from premature dissociation and interaction with dietary inhibitors, preserving its intact structure until reaching target cells.
2. Enhanced Cellular Uptake — liposomes fuse directly with intestinal cell membranes, facilitating efficient cellular delivery and bypassing traditional ion-channel absorption limits. The liposomes are absorbed via lipid-mediated pathways, delivering magnesium directly into systemic circulation and cells.
3. Superior Bioavailability — A randomized controlled trial comparing 400 mg liposomal magnesium versus 400 mg standard magnesium demonstrated that the liposomal group reached maximum serum concentration at 6 hours versus 2 hours for the standard group, with significantly higher serum magnesium levels at 2, 4, 6, 8, 10, and 12 hours. Data shows that liposomal magnesium is 5× more bioavailable than standard magnesium. Another study by Krawinkel et al. (2021) demonstrated that liposomal encapsulation significantly improves magnesium bioavailability compared to conventional salts, resulting in higher serum magnesium and improved intracellular uptake.
| Field | Details |
|---|---|
| Product Name | Liposomal Magnesium Glycinate 80% |
| CAS No. | 14783-68-7 |
| Active Ingredient | Magnesium Bisglycinate (Chelated Magnesium) |
| Assay Method | HPLC for magnesium glycinate quantification; ICP-MS for elemental magnesium content and heavy metal analysis; TEM for liposome vesicle structure confirmation; DLS for particle size distribution verification |
| Purity | ≥ 80% magnesium glycinate; ≥ 15% elemental magnesium |
| Appearance / Color | White to off-white or light yellow free-flowing powder |
| Dosage Form | Liposomal powder, water-dispersible |
| Recommended Dosage | 200–400 mg elemental magnesium per day; 2–4 capsules daily provides approximately 200–400 mg elemental magnesium |
| Application | Muscle relaxation, nervous system support, sleep quality, stress management, metabolic function, bone health, cardiovascular support |
| Extract Source | Synthetic chelation (magnesium ion bound to two glycine molecules via proprietary chelation process) |
| Molecular Formula | C₄H₈MgN₂O₄ |
| Molecular Weight | 172.42 g/mol |
| Lead Time | In stock: 3–5 business days; Bulk/custom orders: 2–3 weeks |
| Shipping Method | International Express (FedEx / DHL / UPS); air and sea freight available; worldwide shipping including remote areas |
| Storage | Cool, dry place away from direct sunlight and moisture; keep container tightly sealed |
High Purity — Standardized to ≥80% magnesium glycinate by HPLC, ensuring consistent active content and ≥15% elemental magnesium.
Fully Chelated Structure — Each magnesium molecule is bound to two glycine molecules, creating a stable ring-like chelate structure that mimics natural food nutrients.
Superior Bioavailability — Utilizes the dipeptide transport pathway for absorption, bypassing ion-channel limitations. Research indicates up to 2.5× better absorption than conventional forms.
Liposomal Enhancement — Phospholipid bilayer encapsulation achieves encapsulation efficiency ≥90%, with 100–300 nm particle size confirmed by TEM imaging, delivering 2–5× higher bioavailability compared to non-liposomal magnesium glycinate.
Gentle on Digestion — Does not neutralize stomach acid or cause the laxative effect frequently associated with magnesium oxide and citrate. Ideal for individuals with sensitive stomachs.
Synergistic Glycine Benefit — The glycine component acts as a calming neurotransmitter, offering simultaneous benefits for muscle relaxation and sleep quality.
Water-Dispersible — Dispersible in water, forming a stable emulsion; suitable for capsules, tablets, powder drink mixes, and functional beverages.
Batch Traceability — Complete COA, HPLC chromatogram, TEM report, heavy metal analysis, and elemental magnesium assay data provided for each batch.
| Application | Recommended Usage | Notes |
|---|---|---|
| Capsules / Tablets | 200–400 mg elemental magnesium per serving | Take in the evening to leverage glycine‘s calming effects |
| Functional Beverages | 100–200 mg per 250 mL | Water-dispersible; suitable for RTD formats including sleep and relaxation drinks |
| Powdered Drink Mixes | 200–400 mg per sachet | Blend with vitamin B6 for synergistic nervous system support |
| Sleep & Relaxation Formulas | 200–400 mg per serving | Often combined with L-theanine, GABA, or melatonin |
| Sports Nutrition | 200–400 mg per serving | Combine with potassium and taurine for muscle recovery |
Clinical studies commonly recommend 200–400 mg of elemental magnesium per day from magnesium glycinate. A typical dosing regimen of 2–4 capsules daily provides approximately 200–400 mg elemental magnesium. Magnesium glycinate is best taken in the evening to leverage the calming effects of the glycine component. Liposomal formulations may allow for more efficient utilization of lower doses due to enhanced delivery efficiency.
Stock Orders: 3–5 business days after payment confirmation.
Bulk / Custom Orders: 2–3 weeks, depending on quantity and customization requirements.
Shipping Methods: International Express (FedEx, DHL, UPS), air freight, and sea freight.
Coverage: Worldwide shipping, including remote areas.
Magnesium Glycinate Encyclopedia — Scientific Background
Magnesium glycinate, also known as magnesium bisglycinate, is a chelated form of magnesium in which the mineral is bound to the amino acid glycine. Chemically, it consists of a magnesium ion bound to two molecules of glycine, creating a stable, ring-like structure (chelate) that mimics the structure of natural nutrients found in food. This chelation process transforms magnesium into an amino acid chelate mineral that the body recognizes as a protein building block rather than just a mineral salt.
| Property | Value |
|---|---|
| CAS No. | 14783-68-7 |
| Molecular Formula | C₄H₈MgN₂O₄ |
| Molecular Weight | 172.42 g/mol |
| Appearance | White to off-white or light yellow powder |
| Solubility | Dispersible in water (forms stable emulsion) |
| Elemental Magnesium | 14% (theoretical); ≥15% in standardized products |
The term “chelate” derives from the Greek word “chele,” meaning crab claw, referring to the pincer-like manner in which the amino acid glycine binds to the mineral ion. In magnesium glycinate, two glycine molecules coordinate with a central magnesium ion through their amino and carboxyl groups, forming two stable five-membered rings. This chelate structure is confirmed through FT-IR spectroscopy testing.
Chemical structure of magnesium bisglycinate chelate.
Unlike inorganic magnesium sources such as magnesium oxide that rely on passive diffusion and ion-channel absorption, magnesium glycinate is absorbed in part as an intact dipeptide in the proximal small intestine. The body recognizes the magnesium-glycine complex as a dipeptide, utilizing specific dipeptide transport channels for absorption, bypassing the competitive ion-channel pathways used by other minerals.
Because it travels through dipeptide pathways, magnesium glycinate does not compete with other essential minerals like calcium, iron, or zinc for absorption, and is less likely to bind with dietary inhibitors such as phytates or oxalates. The chelate structure also inhibits the formation of a hydration shell, further enhancing absorption efficiency.
Magnesium glycinate utilizes the dipeptide transport pathway for efficient absorption.
Magnesium is the second most abundant intracellular cation and serves as a cofactor in more than 600 enzyme reactions throughout the body. Key physiological roles include:
Muscle Function — Magnesium regulates muscle contraction and relaxation, and is essential for preventing cramps and spasms
Nervous System — Magnesium modulates NMDA receptor activity and supports GABAergic function for mood stabilization
Energy Production — Magnesium is required for ATP synthesis and is a critical cofactor in mitochondrial Energy Metabolism
Cardiovascular Function — Magnesium regulates heart rhythm, vascular tone, and blood pressure
Bone Health — Approximately 60% of the body‘s magnesium is stored in bones, where it contributes to bone mineral density
The glycine component of magnesium glycinate is not merely a carrier—it is a bioactive amino acid with independent physiological benefits. Glycine is an inhibitory neurotransmitter in the spinal cord and an allosteric regulator of NMDA receptors. It has been shown to lower core body temperature and quiet the nervous system. Magnesium glycinate operates through an integrated mechanism—calming neural excitability, buffering stress reactivity, improving sleep architecture, and restoring vitality.
The mechanisms include:
NMDA Receptor Antagonism — Prevents excitotoxicity and neuronal injury
GABAergic Modulation — Enhances GABA_A receptor activity for mood stabilization
HPA Axis Regulation — Lowers ACTH/cortisol and buffers stress-system hyper-activation
BDNF Enhancement — Supports neuroplasticity through increased Brain-Derived Neurotrophic Factor
liposomal encapsulation of magnesium glycinate provides an additional layer of protection and delivery enhancement beyond the chelation itself. The phospholipid bilayer surrounds the magnesium-glycine complex, forming a shield that protects it from harsh conditions including gastric acid and enzymatic degradation.
The liposomal delivery system uses a phospholipid bilayer to fully encapsulate magnesium glycinate, shielding it from gastric interference and improving solubility. This system delivers intact magnesium directly into intestinal cells and tissues, boosting bioavailability by 2–5× compared to non-liposomal magnesium glycinate. The liposomes are absorbed via lipid-mediated pathways, delivering magnesium directly into systemic circulation and cells with significantly higher efficiency and zero gastric distress.
Magnesium oxide—the most common and least expensive form—contains roughly 60% elemental magnesium by weight but exhibits only 4–23% absorption. In contrast, organic forms such as magnesium glycinate are more bioavailable than inorganic forms, with absorption ranges from 50% to 67% for top organic chelates. A systematic review published in Nutrition found that organic forms (those chelated to organic molecules like amino acids) are more bioavailable than inorganic forms such as magnesium oxide.
The combination of chelation and liposomal encapsulation represents the most advanced delivery strategy for magnesium supplementation, addressing both the absorption limitations of inorganic salts and the stability challenges of conventional chelated forms.
Bioavailability
A randomized controlled trial comparing 400 mg liposomal magnesium versus 400 mg standard magnesium demonstrated that the liposomal group reached maximum serum concentration at 6 hours versus 2 hours for the standard group, with significantly higher serum magnesium levels at 2, 4, 6, 8, 10, and 12 hours. Data shows that liposomal magnesium is 5× more bioavailable than standard magnesium.
Gastrointestinal Tolerance
In a clinical trial with ileal resection patients, magnesium diglycinate was better tolerated by all patients compared to magnesium oxide. Peak isotope enrichment occurred significantly earlier after chelate ingestion (mean difference 3.2 ± 1.3 hours), and the area under the enrichment vs. time curve was greater after chelate ingestion. Magnesium glycinate has high bioavailability and good gastrointestinal tolerance, making it promising as an adjunctive therapy.
Sleep and Nervous System
Magnesium glycinate has strong clinical evidence for sleep, nerve, and muscle function. The calming effects of glycine, combined with magnesium’s role in nervous system regulation, make this chelate particularly suitable for sleep support and stress management formulas.
Magnesium glycinate is generally well tolerated and is renowned for being exceptionally gentle on the gastrointestinal tract. It does not neutralize stomach acid or cause the laxative effect frequently associated with magnesium oxide and magnesium citrate, making it the ideal choice for individuals with sensitive stomachs or low gastric acid levels.
Heavy metal content in liposomal magnesium glycinate products is rigorously controlled, with typical specifications: Lead (Pb) ≤ 3 ppm, Mercury (Hg) ≤ 0.1 ppm, Cadmium (Cd) ≤ 1.0 ppm, and Arsenic (As) ≤ 1.0 ppm, meeting strict global pharmaceutical and food safety standards. Testing protocols must adhere to international standards including USP, European Pharmacopoeia, and FAO/WHO Codex Alimentarius. Formulators should verify local regulatory requirements prior to market entry.
This product is intended for research, nutraceutical, and functional food applications. Not intended to diagnose, treat, cure, or prevent any disease.
69$/KG
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