79$/KG
Liposomal Calcium Glycinate 80% is a premium-grade dietary supplement ingredient delivering calcium bisglycinate in an advanced liposomal delivery system. Calcium glycinate, also known as calcium bisglycinate, is a fully reacted mineral chelate in which each calcium molecule is bound to two glycine molecules through a proprietary chelation process. This structure transforms calcium into an amino acid chelate mineral that the body recognizes as a protein building block rather than an inorganic salt.
Calcium is an essential mineral required for bone and teeth structure, muscle contraction, nerve transmission, blood clotting, and cardiovascular function. However, conventional calcium supplements—particularly calcium carbonate—require stomach acid for dissociation and absorption, making them less effective for individuals with low gastric acid output and frequently causing gastrointestinal discomfort. Calcium glycinate addresses these limitations through its chelated structure and amino acid transport pathway absorption.
Calcium glycinate already offers superior bioavailability compared to inorganic calcium salts. However, liposomal encapsulation further enhances its performance through a biomimetic phospholipid bilayer that protects the mineral-chelate complex during digestive transit and facilitates efficient cellular delivery.
Liposomal encapsulation provides three critical advantages:
1. Digestive Protection — The phospholipid bilayer shields the calcium-glycine chelate from premature dissociation and interaction with dietary inhibitors, preserving its intact structure until reaching target cells.
2. Enhanced Cellular Uptake — liposomes fuse directly with intestinal cell membranes, facilitating efficient cytoplasmic delivery and complementing the amino acid transport pathway utilized by the chelate itself.
3. Thermal Stability — Liposomal calcium exhibits exceptional heat resistance. Even at 105°C for four hours—conditions that degrade most standard supplements—encapsulation efficiency remained at approximately 94.68%, close to the 94.71% measured at room temperature, with a performance drop of less than 0.5%. This thermal stability supports reliable manufacturing processes including spray drying and granulation, and ensures product integrity throughout global shipping and distribution.
Figure 2. Liposomal encapsulation protects the calcium-glycine chelate and enhances cellular delivery.
Figure 3. Batch-specific COA, HPLC chromatogram, and specification sheet available.
High Purity — Standardized to ≥80% calcium glycinate by HPLC, ensuring consistent active content.
Fully Chelated Structure — Each calcium molecule is bound to two glycine molecules, creating a stable ring-like chelate structure that mimics natural food nutrients.
Superior Bioavailability — Utilizes specific amino acid transport channels for absorption, bypassing competitive pathways used by other minerals. Research indicates approximately 44% absorption compared to 22% for non-chelated forms.
Gentle on Digestion — Does not neutralize stomach acid or cause the gas, bloating, and constipation frequently associated with calcium carbonate. Ideal for individuals with sensitive stomachs, IBS, or low gastric acid levels.
Non-Competitive Absorption — Does not compete with iron, zinc, or magnesium for absorption and is less likely to bind with dietary inhibitors like phytates or oxalates.
Dual-Action Relaxation — The glycine component acts as a calming neurotransmitter, offering simultaneous benefits for bone strength and sleep quality or stress reduction.
Thermal Stability — Liposomal encapsulation maintains structural integrity under high-temperature manufacturing conditions and during global shipping.
Water-Dispersible — Soluble in water; suitable for capsules, tablets, powder drink mixes, and functional beverages.
Batch Traceability — Complete COA, HPLC chromatogram, FTIR identity confirmation, and calcium assay data provided for each batch.
| Application | Recommended Usage | Notes |
|---|---|---|
| Capsules / Tablets | 300–500 mg elemental calcium per serving | Take away from meals for optimal absorption; 3 capsules daily provides ~331 mg calcium |
| Functional Beverages | 150–300 mg per 250 mL | Water-dispersible; suitable for RTD formats including dairy alternatives and plant-based milks |
| Powdered Drink Mixes | 300–500 mg per sachet | Blend with vitamin D3 and K2 for synergistic bone support |
| Bone Health Formulas | 300–600 mg per serving | Often combined with vitamin D, magnesium, boron, and vitamin K2 |
| Sleep Support Formulas | 200–400 mg per serving | Take in the evening to leverage glycine's calming effects |
Figure 4. Liposomal Calcium Glycinate 80% is suitable for capsules, beverages, and functional foods.
Clinical studies and commercial products commonly recommend 300–600 mg of elemental calcium per day from calcium glycinate. A typical dosing regimen of 3 capsules daily provides approximately 331 mg of elemental calcium, covering 41% of the Nutrient Reference Value (NRV). Calcium glycinate is best taken away from meals for optimal absorption, as food can interfere with the amino acid transport pathway. Liposomal formulations may allow for more efficient utilization of lower doses due to enhanced delivery efficiency.
Stock Orders: 3–5 business days after payment confirmation.
Bulk / Custom Orders: 2–3 weeks, depending on quantity and customization requirements.
Shipping Methods: International Express (FedEx, DHL, UPS), air freight, and sea freight.
Coverage: Worldwide shipping, including remote areas.
Calcium Glycinate Encyclopedia — Scientific Background
Calcium glycinate, also known as calcium bisglycinate, is a chelated form of calcium in which the mineral is bound to the amino acid glycine. Chemically, it consists of a calcium ion bound to two molecules of glycine, creating a stable, ring-like structure (chelate) that mimics the structure of natural nutrients found in food. This chelation process transforms calcium into an amino acid chelate mineral that the body recognizes as a protein building block rather than just a mineral salt.
| Property | Value |
|---|---|
| CAS No. | 35947-07-0 |
| Molecular Formula | C₄H₈CaN₂O₄ |
| Molecular Weight | 188.20 g/mol |
| IUPAC Name | Calcium bis(2-aminoacetate) |
| EINECS | 252-809-5 |
| Appearance | White to off-white crystalline powder |
| Solubility | Soluble in water; slightly soluble in ethanol |
| Taste | Slightly sweet |
The term “chelate” derives from the Greek word “chele,” meaning crab claw, referring to the pincer-like manner in which the amino acid glycine binds to the mineral ion. In calcium glycinate, two glycine molecules coordinate with a central calcium ion through their amino and carboxyl groups, forming two stable five-membered rings. This chelate structure is confirmed through FT-IR spectroscopy testing, which identifies characteristic absorption peaks associated with the Ca–N and Ca–O bonds.
Figure 5. Chemical structure of calcium bisglycinate chelate.
Unlike inorganic calcium sources such as calcium carbonate that rely on stomach acid to break them down, calcium glycinate is absorbed efficiently regardless of stomach pH. The body recognizes the calcium-glycine complex as an amino acid rather than just a mineral salt, and utilizes specific amino acid transport channels for absorption, bypassing the competitive pathways used by other minerals.
Research indicates that calcium glycinate has a significantly higher absorption rate—often cited as roughly 6% higher than lactate forms—and does not require Vitamin D co-ingestion to facilitate uptake. Studies show that chelated forms like calcium bisglycinate can be absorbed nearly twice as well as non-chelated versions. When taken away from food, approximately 44% of calcium from calcium bisglycinate is absorbed, compared to approximately 22% from non-chelated forms.
Because it travels through amino acid pathways, calcium glycinate does not compete with other essential minerals like iron, zinc, or magnesium for absorption, and is less likely to bind with dietary inhibitors such as phytates or oxalates found in fiber-rich foods.
Figure 6. Calcium glycinate utilizes amino acid transport channels for efficient absorption.
Calcium is the most abundant mineral in the human body, with approximately 99% stored in bones and teeth. Beyond structural support, calcium plays critical roles in:
Muscle Contraction — Calcium triggers the interaction between actin and myosin filaments necessary for muscle movement
Nerve Transmission — Calcium ions are essential for neurotransmitter release at synaptic junctions
Blood Clotting — Calcium is a cofactor for multiple clotting factors in the coagulation cascade
Cardiovascular Function — Calcium regulates heart rhythm and vascular tone
Hormone Secretion — Calcium signaling is required for the release of various hormones
The glycine component of calcium glycinate is not merely a carrier—it is a bioactive amino acid with independent physiological benefits. Glycine is an inhibitory neurotransmitter in the spinal cord and an allosteric regulator of NMDA receptors. It has been shown to lower core body temperature and quiet the nervous system. Therefore, calcium glycinate offers a dual benefit: strengthening bones while simultaneously promoting better sleep quality and reducing stress or anxiety.
Liposomal encapsulation of calcium glycinate provides an additional layer of protection and delivery enhancement beyond the chelation itself. The phospholipid bilayer surrounds the calcium-glycine complex, forming a shield that protects it from harsh conditions including high heat. This delivery method imitates how natural cell membranes work, offering strong protection while remaining compatible with the body.
Liposomal calcium has demonstrated exceptional thermal stability, maintaining encapsulation efficiency of approximately 94.7% even after exposure to 105°C for four hours. DSC analysis reveals that liposomal calcium shows distinct thermal behavior with events at 293.47°C and 453.18°C, indicating solid molecular links between the lipid bilayer and the mineral inside—the phospholipid bilayer acts as a barrier against direct heat, shielding the calcium core.
Calcium glycinate is widely used to support bone mineral density and reduce the risk of osteoporosis. Studies in mice and rats demonstrate the potential for using calcium glycinate as an agent compensating for bone tissue calcium deficiency. Commercial calcium glycinate supplements are formulated to support the maintenance of bone mass and integrity, often combined with vitamin D, boron, and vitamin K2 for synergistic bone metabolism support.
Calcium glycinate is highly effective at regulating muscle contractions, helping to prevent muscle cramps and spasms while supporting healthy blood pressure regulation and heart rhythm.
Comparative studies indicate that chelated calcium forms such as calcium bisglycinate achieve approximately twice the absorption rate of non-chelated forms when taken away from food. The amino acid transport pathway utilization represents a fundamentally different absorption mechanism from passive diffusion utilized by inorganic calcium salts.
Calcium glycinate is generally well tolerated and is renowned for being exceptionally gentle on the gastrointestinal tract. It does not neutralize stomach acid or cause the gas, bloating, and constipation frequently associated with cheaper calcium supplements, making it the ideal choice for individuals with sensitive stomachs, IBS, or low gastric acid levels such as the elderly. Testing protocols must adhere to international standards including USP, European Pharmacopoeia, and FAO/WHO Codex Alimentarius, with GMP and ISO 17025 accreditation critical for laboratories conducting these analyses. Formulators should verify local regulatory requirements prior to market entry.
This product is intended for research, nutraceutical, and functional food applications. Not intended to diagnose, treat, cure, or prevent any disease.
79$/KG
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