Liposomal Glycine-Iron 80% — High Bioavailability Chelated Iron Supplement Product Overview Liposomal Glycine-Iron 80% is a premium-grade dietary supplement ingredient delivering ferrous bisglycinate in an advanced liposomal delivery system. Ferrous bisglycinate, also known as iron bisglycinate or ferrous glycinate, is a fully reacted amino acid chelate in which a central ferrous iron ion is covalently bonded to the alpha-amino and carboxylate groups of two glycine molecules. This chelation process results in the formation of two stable, five-membered heterocyclic rings—a structural feature fundamental to its enhanced bioavailability and tolerability. Iron is an essential mineral required for hemoglobin synthesis, oxygen transport, electron transfer, and numerous enzymatic reactions. Conventional iron supplements—particularly ferrous sulfate and ferrous fumarate—exhibit poor bioavailability and frequently cause gastrointestinal side effects including nausea, cramping, constipation, and dark stools. Ferrous bisglycinate addresses these limitations through its chelated structure and dual absorption pathway, while liposomal encapsulation provides an additional layer of protection and delivery enhancement. Why Liposomal Technology? Ferrous bisglycinate already offers superior bioavailability and gastrointestinal tolerance compared to conventional iron salts. A systematic review and meta-analysis of 17 randomized controlled trials demonstrated that ferrous bisglycinate supplementation resulted in higher hemoglobin concentrations in pregnant women compared with other iron supplements and significantly fewer gastrointestinal adverse events. Liposomal encapsulation further enhances its performance through a biomimetic phospholipid bilayer that protects the iron-chelate complex during digestive transit and facilitates efficient cellular delivery. Liposomal encapsulation provides three critical advantages: 1. Gastric Protection — The phospholipid bilayer shields the iron-glycine chelate from gastric acid degradation and interaction with dietary inhibitors including phytates, tannins, and calcium, preserving its intact structure until reaching optimal absorption sites in the small intestine. 2. Enhanced Absorption via Lymphatic Pathway — Liposomal iron utilizes endocytosis to enter cells directly, bypassing the DMT1 absorption ceiling entirely. Liposomes also utilize a lymphatic absorption route, allowing rapid, efficient results. The lipid bilayer protects against acid and food inhibitors, with bioavailability 3 to 5 times higher than ordinary iron. 3. Zero Gut Contact — Minimized Side Effects — Liposomal encapsulation minimizes direct contact between iron and the gastrointestinal mucosa, preventing the Fenton reaction that generates free radicals and causes nausea, cramping, and constipation. The liposomal formulation achieves a high encapsulation efficiency of 87.42% and a loading capacity of 71%. Product Specifications Field Details Product Name Liposomal Glycine-Iron 80% CAS No. 20150-34-9 Active Ingredient Ferrous Bisglycinate (Iron Bisglycinate Chelate) Assay Method RP-HPLC with post-column derivatization using PAR reagent for Fe(II) detection; ICP-MS for elemental iron content and heavy metal analysis; FTIR for chelation structure confirmation; DLS for particle size distribution; TEM for liposome vesicle structure confirmation Purity ≥ 80% ferrous bisglycinate; ≥ 20% elemental iron Appearance / Color Light to dark greenish powder Dosage Form Liposomal powder, water-dispersible Recommended Dosage 25–75 mg elemental iron per day for maintenance; 100–200 mg per day for iron deficiency; 1–2 capsules daily with food Application Iron deficiency anemia, hemoglobin formation, oxygen transport, energy metabolism, cognitive function, immune support, pregnancy support Extract Source Synthetic chelation (ferrous iron bound to two glycine molecules via proprietary chelation process) Molecular Formula C₄H₈FeN₂O₄ Molecular Weight 203.96 g/mol Lead Time In stock: 3–5 business days; Bulk/custom orders: 2–3 weeks Shipping Method International Express (FedEx / DHL / UPS); air and sea freight available; worldwide shipping including remote areas Storage Cool, dry place away from direct sunlight and moisture; keep container tightly sealed. Protect from light and heat Key Features High Purity — Standardized to ≥80% ferrous bisglycinate by HPLC, ensuring consistent active content and ≥20% elemental iron. Fully Chelated Structure — Each ferrous iron ion is bound to two glycine molecules, creating a stable ring-like chelate structure that protects iron from dietary inhibitors. Dual Absorption Pathway — Absorbed intact through peptide transporters on enterocytes, bypassing the pH-dependent DMT1 pathway used by ionic iron salts. Superior Bioavailability — Studies demonstrate 2–4 times greater absorption compared to ferrous sulfate on a milligram-for-milligram basis. Liposomal Enhancement — Phospholipid bilayer encapsulation achieves 87.42% encapsulation efficiency, 153.8 nm particle size, and −61.22 mV zeta potential, delivering 3–5 times higher absorption than conventional iron. Gentle on Digestion — Because iron remains chelated through the gastric environment, it does not generate free ferrous ions that catalyze Fenton reactions and cause nausea, cramping, and constipation. Water-Dispersible — Suitable for capsules, tablets, powder drink mixes, and functional beverages. Batch Traceability — Complete COA, HPLC chromatogram, FTIR identity confirmation, and elemental iron assay data provided for each batch. Application & Formulation Guidance Application Recommended Usage Notes Capsules / Tablets 25–75 mg elemental iron per serving Take with food for optimal tolerance; can be taken with meals without reduced absorption Functional Beverages 15–30 mg per 250 mL Water-dispersible; no metallic taste Powdered Drink Mixes 25–75 mg per sachet Blend with vitamin C for enhanced absorption Pregnancy Support Formulas 30–60 mg per serving Ferrous bisglycinate is better tolerated and improves hemoglobin in pregnant women Pediatric / Sensitive Stomach Formulas 10–25 mg per serving Gentle on the stomach; minimizes GI side effects Recommended Dosage Clinical studies and commercial products commonly recommend 25–75 mg of elemental iron per day for maintenance in healthy adults and 100–200 mg per day for iron deficiency. A typical dosing regimen of 1–2 capsules daily provides approximately 25–50 mg elemental iron per serving. Ferrous bisglycinate can be taken with meals without the typical reduction in absorption seen with ionic iron forms, offering greater flexibility in dosing. Co-supplementation with vitamin C further enhances absorption. Iron status should be monitored through ferritin and transferrin saturation to guide dosing. Shipping & Lead Time Stock Orders: 3–5 business days after payment confirmation. Bulk / Custom Orders: 2–3 weeks, depending on quantity and customization requirements. Shipping Methods: International Express (FedEx, DHL, UPS), air freight, and sea freight. Coverage: Worldwide shipping, including remote areas.