Product Detailed Description

Liposomal EGCG 50% Green Tea Extract Powder — High Purity 70% Antioxidant Supplement

Product Overview

liposomal egcg 50% Green Tea Extract Powder is a premium, high-purity antioxidant supplement delivering 50% epigallocatechin gallate (EGCG) and 70% total green tea catechins, encapsulated in advanced liposomal delivery technology. Derived from organically cultivated Camellia sinensis leaves, this water-dispersible powder is designed for superior bioavailability, enhanced stability, and precise formulation flexibility across nutraceutical, functional food, and beverage applications.

Why Liposomal Technology?

Standard green tea extracts deliver only 12–25% of EGCG into systemic circulation due to poor stability in the alkaline small intestine, rapid phase II metabolism in the liver, and limited passive diffusion across intestinal cells. Liposomal encapsulation addresses these limitations through a biomimetic phospholipid bilayer that serves three critical functions simultaneously:

1. Physical Shielding — Protects catechins from gastric acid and intestinal alkaline degradation throughout the digestive tract.

2. Direct Membrane Fusion — liposomes fuse naturally with intestinal cell membranes, bypassing passive diffusion for direct cytoplasmic delivery.

3. Sustained Release — Gradual degradation in circulation extends the window of plasma concentration, functioning as a built-in time-release mechanism.

Studies demonstrate that liposomal encapsulation of EGCG achieves encapsulation efficiency exceeding 90% and significantly improves both stability and cellular bioavailability compared to conventional free-form EGCG.

Product Specifications

Key Features

• High Potency — Standardized to 50% EGCG and 70% total catechins, ensuring consistent and reliable antioxidant activity.

• Enhanced Bioavailability — Liposomal delivery significantly improves intestinal absorption and cellular uptake compared to non-encapsulated EGCG.

• Superior Stability — Phospholipid bilayer protection maintains EGCG integrity against heat, pH variation, and oxidative degradation.

• Water-Dispersible — Suitable for a wide range of formulation applications including capsules, tablets, functional beverages, and powdered drink mixes.

• Clean-Label Compatible — Plant-derived phospholipids, no synthetic excipients, suitable for clean-label product development.

Application & Formulation Guidance

Recommended Storage

Store in a cool, dry place away from direct sunlight and moisture. Keep container tightly sealed when not in use. Optimal storage temperature: 2–8°C for extended shelf life.

EGCG Encyclopedia — Scientific Background

What Is EGCG?

Epigallocatechin gallate (EGCG) is the predominant catechin in green tea, comprising approximately 50% of its total polyphenol content and representing 50–80% of total catechins. As the principal bioactive component of Camellia sinensis, EGCG is a flavon-3-ol polyphenolic compound containing eight free hydroxyl groups responsible for its diverse bioactivities.

Botanical Origin

Green tea is derived from the unoxidized leaves of Camellia sinensis (L.) Kuntze, one of the least processed types of tea and rich in antioxidants and polyphenols. Catechins—a category of flavanols belonging to the flavonoid subclass—are the principal secondary metabolites in tea, with the main components including catechin, epicatechin, epicatechin gallate, epigallocatechin, and EGCG.

Bioactive Properties

EGCG exhibits a wide spectrum of biological activities, including:

• Antioxidant — EGCG demonstrates strong antioxidant capacity to inhibit reactive oxygen species (ROS) generation by scavenging free radicals and chelating metal ions.

• Anti-inflammatory — EGCG suppresses nuclear factor kappa-B (NF-κB), a pivotal signaling molecule in inflammation progression.

• Anticancer — EGCG modulates tumor-driven signaling cascades, promoting programmed cell death selectively in abnormal cells while sparing healthy tissue.

• Cardioprotective — Influences key physiological pathways related to lipid metabolism and inflammation.

• Neuroprotective — Safeguards neurons from damage and enhances cognitive function through antioxidant capacity to reduce ROS generated during physiological stress.

• Metabolic Regulation — Involved in regulating apoptosis and cell cycle progression, showing promise for managing metabolic diseases including diabetes.

Mechanisms of Action

Antioxidant Defense

EGCG reduces oxidative stress through multiple pathways: directly scavenging free radicals, inhibiting ROS-generating mechanisms, and upregulating antioxidant enzymes. Studies demonstrate that EGCG treatment at 25–50 μM significantly increases catalase, superoxide dismutase (SOD1 and SOD2), and Glutathione peroxidase gene expressions and enzyme activities, protecting cells against H₂O₂-induced oxidative damage.

Anti-Inflammatory Pathways

EGCG enhances the activities of Sirtuin 1 (Sirt1) to induce autophagy, protecting against inflammation injury and oxidative stress in tissues and organs. It also modulates key signaling pathways such as JAK/STAT, Delta-Notch, and TNF, all of which play critical roles in cellular survival, growth, and function.

Mitochondrial Protection

Recent studies suggest EGCG exerts beneficial effects by modulating mitochondrial functions, impacting mitochondrial biogenesis, bioenergetic control (ATP production), alteration of the cell cycle, and mitochondria-related apoptosis.

Clinical Evidence

A systematic review of 17 clinical studies classified EGCG interventions into five key areas: toxicity and detoxification, drug pharmacokinetics, cognitive functions, anti-inflammatory and antioxidant properties, and obesity and metabolism. Findings suggest that the health benefits of green tea catechins outweigh the potential risks. EGCG has shown therapeutic advantages in oral infections, cancer, obesity, diabetes, neurodegenerative disorders, and inflammatory diseases.

The Bioavailability Challenge

Despite its promising therapeutic potential, EGCG's clinical use is constrained by limited bioavailability. The compound's distinctive architecture—particularly its ortho-dihydroxy and vicinal-trihydroxy moieties—confers potent bioactivity but simultaneously acts as a structural liability, driving oxidative degradation and epimerization. Conventional oral administration results in poor absorption, rapid metabolism, and limited tissue distribution. This challenge has driven the development of advanced delivery systems, with liposomal encapsulation emerging as one of the most effective strategies for enhancing EGCG stability and bioavailability in functional food and nutraceutical applications

199$/KG

169$/KG