69$/KG
Product Detailed Description
liposomal Magnesium Malate 80% is a premium-grade dietary supplement ingredient delivering magnesium malate in an advanced liposomal delivery system. Magnesium malate is the magnesium salt of malic acid, an organic compound naturally present in apples, grapes, and other fruits. Each magnesium ion is chelated with malate through its carboxylate groups, forming a stable, water-soluble organic mineral complex with a molecular formula of C₄H₄MgO₅ (anhydrous form) and a molecular weight of approximately 156.38 g/mol.
Magnesium is an essential mineral involved in more than 600 biochemical reactions in the body, contributing to normal Energy Metabolism, muscle function, nerve function, and psychological well-being. Malate is a key intermediate in the Krebs cycle and plays a critical role in ATP production through oxidative phosphorylation. The combination of magnesium and malate in a single chelated complex provides targeted support for cellular energy metabolism and neuromuscular function.
Magnesium malate already offers superior bioavailability compared to inorganic magnesium salts such as magnesium oxide, thanks to the chelation of magnesium with malic acid. Organic magnesium salts (malate, citrate) and amino acid chelates demonstrate significantly higher absorption rates by utilizing alternative transport pathways. The water-soluble nature of magnesium malate allows it to dissolve efficiently regardless of stomach pH, making it suitable for individuals with low gastric acid output.
Liposomal encapsulation further enhances its performance through a biomimetic phospholipid bilayer that protects the magnesium-chelate complex during digestive transit and facilitates efficient cellular delivery.
Liposomal encapsulation provides four critical advantages:
1. Gastric Protection — The phospholipid bilayer shields the magnesium-malate complex from gastric acid degradation and interaction with dietary inhibitors, preserving its intact structure until reaching optimal absorption sites in the small intestine.
2. Enhanced Cellular Uptake via Endocytosis — The liposomal delivery system utilizes "endocytosis" to allow direct penetration through the intestinal wall, far exceeding traditional magnesium malate. This mechanism bypasses the digestive system entirely, delivering magnesium and malate directly into the bloodstream.
3. Gastrointestinal Friendliness — Active magnesium is shielded by phospholipids, preventing direct contact with intestinal mucosa and reducing osmotic diarrhea risk commonly associated with conventional magnesium forms.
4. Enhanced Stability — The phospholipid bilayer resists gastric acid erosion, ensuring core ingredients are released at the optimal small intestine absorption site.
High Purity — Standardized to ≥80% magnesium malate with elemental magnesium content ≥10.0%, ensuring consistent active content.
Dual-Action Metabolic Support — Combines magnesium, an essential enzyme cofactor, with malate, a key Krebs cycle intermediate, in a single stable organic complex.
Superior Bioavailability — Magnesium malate demonstrates higher absorption rates than inorganic magnesium salts, utilizing organic acid transport pathways for efficient uptake.
Liposomal Enhancement — Phospholipid bilayer encapsulation achieves encapsulation efficiency ≥90%, with endocytosis-mediated cellular uptake that bypasses the digestive system for direct absorption.
Gentle on Digestion — Magnesium malate is known for its excellent gastrointestinal tolerance, and liposomal encapsulation further reduces the risk of osmotic diarrhea and digestive discomfort.
ATP Energy Synthesis — Magnesium is a key cofactor in the Krebs cycle, supporting efficient ATP production and cellular metabolism.
Muscle and Nerve Support — Aids in neuromuscular signaling and relaxation, helping alleviate cramps and stress.
Water-Dispersible — Soluble in water (>50 g/100 mL); suitable for capsules, tablets, powder drink mixes, and functional beverages.
Batch Traceability — Complete COA, HPLC chromatogram, and identity data provided for each batch.
| Application | Recommended Usage | Notes |
|---|---|---|
| Capsules / Tablets | 100–300 mg elemental magnesium per serving | 1–3 capsules daily with meals |
| Functional Beverages | 50–150 mg per 250 mL | Water-soluble; suitable for RTD formats |
| Powdered Drink Mixes | 100–300 mg per sachet | Blend with B-vitamins for synergistic energy metabolism support |
| Sports Recovery Formulas | 200–400 mg per serving | Often combined with CoQ10 or L-carnitine |
| Fibromyalgia Support Formulas | 300–600 mg per serving | Clinical trial used 300–600 mg magnesium with 1,200–2,400 mg malate daily |
Clinical studies and commercial products commonly recommend 100–425 mg of elemental magnesium per day from magnesium malate. A typical dosing regimen of 1–3 capsules daily provides approximately 100–300 mg elemental magnesium. Most magnesium malate supplements provide 100 to 425 milligrams of elemental magnesium for each dose.
The Tolerable Upper Intake Level (UL) for supplemental magnesium is 350 mg daily for adults. Typical magnesium malate supplement dosages range from 200–800 mg daily, usually divided into 2–3 doses with meals to enhance absorption and minimize digestive upset.
For fibromyalgia support, an early open-label, crossover trial by Abraham and Flechas treated 15 fibromyalgia patients with a combination of 300–600 mg of magnesium and 1,200–2,400 mg of malate daily for 8 weeks, reporting significant improvement in Tender Point Index scores and myalgia symptoms.
Liposomal formulations may allow for more efficient utilization of lower doses due to enhanced bioavailability.
Stock Orders: 3–5 business days after payment confirmation.
Bulk / Custom Orders: 2–3 weeks, depending on quantity and customization requirements.
Shipping Methods: International Express (FedEx, DHL, UPS), air freight, and sea freight.
Coverage: Worldwide shipping, including remote areas.
Magnesium Malate Encyclopedia — Scientific Background
Magnesium malate is the magnesium salt of malic acid (2-hydroxybutanedioic acid), an organic compound naturally present in apples, grapes, and other fruits. It is a chelated mineral complex in which each magnesium ion (Mg²⁺) is bound to malate anions through their carboxylate groups, forming a stable, water-soluble organic salt. Magnesium malate exists in various forms, including the anhydrous form, dihydrate, and trihydrate.
| Property | Value |
|---|---|
| CAS No. | 869-06-7 |
| Molecular Formula | C₄H₄MgO₅ (anhydrous) |
| Molecular Weight | 156.38 g/mol (anhydrous) |
| IUPAC Name | Magnesium 2-hydroxybutanedioate |
| EC Number | 212-784-3 |
| Appearance | White, odorless, crystalline powder |
| Solubility | Soluble in water (>50 g/100 mL) |
| Melting Point | 165.15 °C |
| pH (in solution) | 5.0–9.0 |
Magnesium malate is formed through the chelation of magnesium with malic acid. Malic acid is a dicarboxylic acid (C₄H₆O₅) that serves as a key intermediate in the Krebs cycle. In the chelation process, magnesium ions coordinate with the carboxylate groups of malate, forming a stable organic mineral complex. This chelate structure is confirmed through FT-IR spectroscopy testing.
Malate is a key intermediate in the Krebs cycle (citric acid cycle, TCA cycle), the central metabolic pathway that converts carbohydrates, fats, and proteins into carbon dioxide and chemical energy in the form of ATP. Malate is oxidized to oxaloacetate by malate dehydrogenase in the final step of the Krebs cycle, generating NADH that feeds into the electron transport chain for ATP production. Malate is an important Krebs cycle intermediate, indicating that it is an important molecule in the production of cellular energy derived from carbohydrates.
The combination of magnesium and malate in a single complex provides a unique dual-action benefit: magnesium acts as a cofactor for the enzymes that catalyze Krebs cycle reactions, while malate serves as a direct substrate for the cycle. This synergy supports efficient cellular energy production at every step.
Magnesium is the second most abundant intracellular cation and serves as a cofactor in more than 600 enzyme reactions throughout the body. Key physiological roles include:
Energy Production — Magnesium is required for ATP synthesis and is a critical cofactor in mitochondrial Energy Metabolism
Muscle Function — Magnesium regulates muscle contraction and relaxation, and is essential for preventing cramps and spasms
Nervous System — Magnesium modulates NMDA receptor activity and supports GABAergic function for mood stabilization
Cardiovascular Function — Magnesium regulates heart rhythm, vascular tone, and blood pressure
Bone Health — Approximately 60% of the body's magnesium is stored in bones, where it contributes to bone mineral density
Magnesium malate is absorbed efficiently through the intestinal mucosa via organic acid transport pathways. Organic magnesium salts (malate, citrate) and amino acid chelates demonstrate significantly higher absorption rates by utilizing alternative transport pathways compared to inorganic salts. The water-soluble nature of magnesium malate allows it to dissolve efficiently regardless of stomach pH, making it suitable for individuals with low gastric acid output.
Because it travels through organic acid pathways, magnesium malate does not compete with other essential minerals like calcium, iron, or zinc for absorption, and is less likely to bind with dietary inhibitors.
Fibromyalgia is a chronic condition characterized by widespread musculoskeletal pain, fatigue, and sleep disturbances. Some research suggests that magnesium deficiency may play a role in its pathophysiology. An early open-label, crossover trial by Abraham and Flechas treated 15 fibromyalgia patients with a combination of 300–600 mg of magnesium and 1,200–2,400 mg of malate daily for 8 weeks. The study reported a significant improvement in Tender Point Index scores and myalgia symptoms.
A randomized, double-blind, placebo-controlled, crossover pilot study by Russell et al. in 1995 investigated the efficacy of "Super Malic," a supplement containing 200 mg of malic acid and 50 mg of magnesium per tablet, in 24 patients with primary fibromyalgia. The results were modest but laid the groundwork for further investigation.
Chronic fatigue syndrome (CFS) is a complex disorder characterized by extreme fatigue that is not improved by rest. The role of magnesium in energy production suggests a potential benefit in CFS. Some studies have found lower red blood cell magnesium levels in CFS patients. A 1991 study published in The Lancet found that intramuscular magnesium sulfate injections improved symptoms in CFS patients. While direct studies on magnesium malate for CFS are limited, its potential to support energy metabolism through both magnesium and malate makes it a compound of interest.
liposomal encapsulation of magnesium malate provides an additional layer of protection and delivery enhancement beyond the chelation itself. The phospholipid bilayer surrounds the magnesium-malate complex, forming a shield that protects it from gastric acid and enzymatic degradation.
The liposomal delivery system utilizes "endocytosis" to allow direct penetration through the intestinal wall, far exceeding traditional magnesium malate. This allows magnesium and malic acid to get directly into the bloodstream, bypassing the digestive system. When placed in consumable or drinkable products, the liposomes are absorbed through the lining of the stomach or intestine, and are absorbed without digestion.
Optimized liposomal magnesium malate formulations achieve encapsulation efficiency of approximately 90% and demonstrate excellent water dispersibility and stability.
Magnesium malate is generally well tolerated and is known for its excellent gastrointestinal safety profile. It does not cause the laxative effect frequently associated with magnesium oxide and magnesium citrate, making it the ideal choice for individuals with sensitive stomachs.
For adults, staying under 350 milligrams per day of magnesium from supplements is considered safe. Taking too much magnesium can cause serious health problems, and extremely high amounts—around 5,000 milligrams per day or more—can cause magnesium toxicity. Magnesium supplements can interfere with many common medications, including diuretics, antibiotics, osteoporosis medications, high blood pressure medications, and heartburn treatments. People with a history of kidney or heart issues need to be especially cautious before starting magnesium supplementation.
Magnesium malate is widely commercialized as a dietary supplement ingredient. Testing protocols must adhere to international standards including USP, European Pharmacopoeia, and FAO/WHO Codex Alimentarius. Formulators should verify local regulatory requirements prior to market entry.
This product is intended for research, nutraceutical, and functional food applications. Not intended to diagnose, treat, cure, or prevent any disease.
69$/KG
RELATED
RELATED
RELATED
RELATED
This website uses cookies to ensure you get the best experience on our website.
Español
Français
Deutsch
日本語
한국어
Phone
Comment
（0）