99$/KG
89$/KG
Product Detailed Description
liposomal L-Tyrosine 70% is a premium-grade dietary supplement ingredient delivering L-tyrosine in an advanced liposomal delivery system. L-Tyrosine (CAS 60-18-4), also known as (S)-2-amino-3-(4-hydroxyphenyl)propanoic acid, is a non-essential aromatic amino acid with the molecular formula C₉H₁₁NO₃ and a molecular weight of 181.19 g/mol. It is a white crystalline powder that is very slightly soluble in water (approximately 0.45 g/L at 25°C) and practically insoluble in ethanol. L-Tyrosine is synthesized in animals from L-phenylalanine via the enzyme phenylalanine hydroxylase and is a precursor for the biosynthesis of dopamine, epinephrine, norepinephrine, and melanin.
L-Tyrosine is a conditionally essential amino acid, meaning that under normal physiological conditions the body can synthesize sufficient amounts from phenylalanine, but during periods of high stress, the demand for catecholamine synthesis may exceed endogenous production capacity. L-Tyrosine is an intermediary in the biosynthesis of dopamine, epinephrine, and norepinephrine, and the first step of the catecholamine biosynthetic route from L-tyrosine is catalyzed by tyrosine hydroxylase. In the central nervous system, catecholamine neurotransmitters participate in regulating activities such as awakening, attention, and mood.
Conventional L-tyrosine presents significant formulation challenges. The compound has extremely poor water solubility in physiological media (approximately 0.45 mg/mL at neutral pH), which severely limits its dissolution rate and intestinal absorption. Additionally, free L-tyrosine undergoes rapid metabolic clearance, has a short in vivo half-life, and exhibits unstable bioavailability after oral administration. L-Tyrosine uptake can be further reduced by competing amino acids from dietary protein.
Liposomal encapsulation provides four critical advantages:
1. Dramatically Enhanced Solubility and Bioavailability — liposomes can effectively encapsulate poorly water-soluble amino acids such as tyrosine, increasing their apparent solubility and absorption profiles in aqueous biological systems. Nano-formulations significantly improve solubility and dispersion uniformity in aqueous and biological environments, with nanoscale particle size facilitating transcellular absorption and blood-brain barrier penetration. Depending on the ingredient, absorption may increase by 60–70% or two to three times.
2. Protection from Enzymatic Degradation — Nano-carrier protection shields L-tyrosine from enzymatic degradation and pH-induced inactivation in the gastrointestinal tract, enhancing chemical stability. The phospholipid bilayer preserves the intact molecular structure until reaching optimal absorption sites in the small intestine.
3. Enhanced Brain Availability — Lipid nanoparticles can protect L-tyrosine during gastrointestinal transit, promote lymphatic circulation absorption, and enhance accumulation in brain and neural tissues, which is especially suitable for neurological and cognitive intervention applications. This is particularly important because dopamine neurons in the prefrontal cortex—a brain region involved in response inhibition and working memory—are highly tyrosine-dependent.
4. Sustained Release for Prolonged Cognitive Support — Nano-carriers enable sustained and slow release, prolonging action time and reducing frequent administration. Liposomal delivery provides a controlled-release profile that maintains steady plasma amino acid levels, supporting prolonged cognitive benefits.
High Purity — Standardized to ≥70% L-tyrosine by HPLC, ensuring consistent active content.
Liposomal Enhancement — Phospholipid bilayer encapsulation increases apparent solubility and absorption profiles, with absorption increases of 60–70% to two or three times compared to free L-tyrosine.
Catecholamine Precursor — L-Tyrosine is an intermediary in the biosynthesis of dopamine, epinephrine, and norepinephrine, and the EFSA has concluded that L-tyrosine contributes to the normal synthesis of dopamine.
Clinically Validated for Cognitive Function Under Stress — L-Tyrosine supplementation has been shown to mitigate working memory decrements during cold exposure and reduce cognitive impairments during environmental stress such as cold induction, acoustic noise, or demanding tasks.
Clinically Validated for Cognitive Fatigue — Health Canada monograph supports the claim that L-tyrosine helps to decrease cognitive fatigue due to physically stressful situations (e.g., extended wakefulness, exposure to cold, excessive noise) at a dose of 10 g, 1–2 times per day.
Dopamine Synthesis Support — The EFSA NDA Panel has concluded that L-tyrosine does contribute to the synthesis of dopamine, supporting its role as a cognitive and mood-support nutrient.
Water-Dispersible — Liposomal powder offers dramatically improved aqueous dispersibility compared to free L-tyrosine; suitable for capsules, tablets, powder drink mixes, and functional beverages.
Batch Traceability — Complete COA, HPLC chromatogram, and identity data provided for each batch.
Clinical studies have evaluated L-tyrosine across a range of doses depending on the application. For general cognitive support, effective doses are usually around 150 mg of L-tyrosine per kilogram of body weight, or about 10 grams for someone who weighs 70 kilograms. For decreasing cognitive fatigue due to physically stressful situations, the Health Canada monograph recommends 10 g, 1–2 times per day, taken up to one hour before or during periods of physical stress. Clinical studies have also used 100–150 mg/kg per day for cognitive performance, while manufacturers commonly recommend 500–1,500 mg/day for general supplementation. L-Tyrosine should be taken on an empty stomach for optimal absorption and benefits, as uptake can be reduced when competing amino acids from dietary protein are present. Tyrosine levels peak 15–60 minutes after taking it, and effects last approximately 1–3 hours, so it should be taken just before the high-stress situation. Liposomal formulations may allow for more efficient utilization of lower doses due to enhanced bioavailability.
Stock Orders: 3–5 business days after payment confirmation.
Bulk / Custom Orders: 2–3 weeks, depending on quantity and customization requirements.
Shipping Methods: International Express (FedEx, DHL, UPS), air freight, and sea freight.
Coverage: Worldwide shipping, including remote areas.
L-Tyrosine Encyclopedia — Scientific Background
L-Tyrosine (CAS 60-18-4), also known as (S)-2-amino-3-(4-hydroxyphenyl)propanoic acid, is a non-essential aromatic amino acid with the molecular formula C₉H₁₁NO₃ and a molecular weight of 181.19 g/mol. It is a white crystalline powder that is very slightly soluble in water (approximately 0.45 g/L at 25°C) and practically insoluble in ethanol. L-Tyrosine is synthesized in animals from L-phenylalanine via the enzyme phenylalanine hydroxylase with tetrahydrobiopterin as a cofactor.
L-Tyrosine's primary physiological role is as the precursor for the catecholamine neurotransmitters dopamine, norepinephrine, and epinephrine. The biosynthesis pathway begins with the conversion of L-tyrosine to L-DOPA by the enzyme tyrosine hydroxylase, which is the rate-limiting step in catecholamine synthesis. L-DOPA is then rapidly decarboxylated to dopamine, which is subsequently converted to norepinephrine and epinephrine. This pathway is particularly important in the prefrontal cortex, where dopamine neurons involved in response inhibition and working memory are highly tyrosine-dependent.
The European Food Safety Authority (EFSA) NDA Panel has concluded that L-tyrosine does contribute to the synthesis of dopamine, supporting its role as a cognitive and mood-support nutrient. During periods of acute stress, catecholamine synthesis and release increase substantially, which can deplete available tyrosine pools and impair cognitive performance—a phenomenon that tyrosine supplementation can potentially mitigate.
The administration of L-tyrosine increases the synthesis capacity and release of dopamine and norepinephrine in the brain. This mechanism underlies tyrosine's cognitive-enhancing effects, particularly under conditions of high stress or demand. L-Tyrosine may boost mental sharpness, especially in short-term, stressful, or demanding situations, by increasing the synthesis of dopamine in the brain and counteracting reductions in working memory and information processing that occur during demanding periods.
L-Tyrosine crosses the blood-brain barrier via the large neutral amino acid transporter (LAT1), which it shares with other large neutral amino acids including tryptophan, phenylalanine, leucine, isoleucine, and valine. The ratio of L-tyrosine to other LNAAs in plasma determines the fraction of tyrosine that reaches the central nervous system, which is why taking tyrosine on an empty stomach (when competing amino acids are low) optimizes its cognitive effects.
L-Tyrosine intervenes in the synthesis of melanin, the pigment responsible for skin, hair, and eye coloration. It is also a precursor for the synthesis of thyroid hormones, which regulate metabolic rate and protein synthesis.
The most robust clinical evidence for L-tyrosine supports its use in mitigating cognitive decline under acute stressors. Health Canada's Natural Health Products Ingredients Database monograph for L-Tyrosine supports the claim that it "helps to decrease cognitive fatigue due to physically stressful situations (e.g., extended wakefulness, exposure to cold, excessive noise)" at a dose of 10 g, 1–2 times per day. Clinical studies have demonstrated that L-tyrosine mitigates working memory decrements during cold exposure and reduces cognitive impairments in young adults during environmental stress such as cold induction, acoustic noise, or demanding tasks.
An ongoing randomized clinical trial (INTENSE) is evaluating the neuro-cognitive effects of tyrosine supplementation in healthy older adults aged 60–75. The study uses a single dose of 150 mg/kg body weight L-tyrosine and measures changes in prefrontal brain activation using fNIRS and EEG during response inhibition and working-memory performance. The study addresses the fact that both prefrontal dopamine availability and prefrontal brain activity decline in the aging brain, and therefore elderly individuals might benefit from tyrosine supplementation to improve cognitive functioning.
Clinical studies have demonstrated that L-tyrosine supplementation reduces cognitive and motor performance deficits during sleep deprivation. This makes tyrosine particularly useful during periods of extended wakefulness, jet lag, or disrupted sleep schedules.
L-Tyrosine is generally well tolerated. A critical review by the EFSA has examined the safety profile of L-tyrosine supplementation, and no significant adverse effects have been reported at recommended doses. The acute toxicity of L-tyrosine is low, consistent with its role as a naturally occurring amino acid.
Despite its important physiological functions, native L-tyrosine presents significant formulation challenges. The compound has extremely poor water solubility at neutral pH (approximately 0.45 mg/mL at 25°C), which severely limits its dissolution rate and intestinal absorption. Free L-tyrosine also undergoes rapid metabolic clearance, has a short in vivo half-life, and exhibits unstable bioavailability after oral administration. L-Tyrosine uptake can be reduced by competing amino acids from dietary protein, which is why it should be taken on an empty stomach.
These limitations have driven the development of advanced delivery systems, including liposomes, solid lipid nanoparticles, nanostructured lipid carriers, and polymeric nanoparticles. Among these, liposomal encapsulation has emerged as one of the most effective strategies for enhancing L-tyrosine solubility, stability, and bioavailability.
Liposomal encapsulation of L-tyrosine provides a fundamentally different delivery mechanism from conventional forms. The phospholipid bilayer surrounds the L-tyrosine molecule, forming a protective shell that enhances solubility, stability, and cellular uptake. This delivery system:
Increases apparent solubility and absorption profiles in aqueous biological systems
Protects L-tyrosine from enzymatic degradation and pH-induced inactivation in the gastrointestinal tract
Facilitates transcellular absorption and blood-brain barrier penetration
Lipid-based nano-formulations including liposomes, solid lipid nanoparticles, and nanostructured lipid carriers are the most widely studied delivery systems for L-tyrosine. Using biocompatible phospholipids and natural lipids, L-tyrosine can be encapsulated in the aqueous core or embedded in the lipid bilayer, with good biocompatibility, biodegradability, and excellent membrane permeability.
L-Tyrosine is generally well tolerated at commonly used doses. Health Canada's monograph recommends a dose of 10 g, 1–2 times per day for occasional use only, with a caution to consult a health care practitioner prior to use if pregnant or breastfeeding, or if following a low protein diet. No specific contraindications or known adverse reactions are required to be stated on the label.
Regulatory status varies by region:
United States — L-Tyrosine is regulated as a dietary supplement ingredient.
European Union — The EFSA NDA Panel has concluded that L-tyrosine contributes to the normal synthesis of dopamine and has established a cause-and-effect relationship for this claim.
Canada — L-Tyrosine is permitted as a Natural Health Product with the claim "Helps to decrease cognitive fatigue due to physically stressful situations" at a dose of 10 g, 1–2 times per day.
L-Tyrosine is monographed in the USP and European Pharmacopoeia with an assay specification of 98.5–101.5%. Testing protocols must adhere to international standards including USP, European Pharmacopoeia, and FAO/WHO Codex Alimentarius. Formulators should verify local regulatory requirements prior to market entry.
This product is intended for research, nutraceutical, and functional food applications. Not intended to diagnose, treat, cure, or prevent any disease.
99$/KG
89$/KG
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