95$/KG
Product Detailed Description
Liposomal L-Lysine 80% is a premium-grade dietary supplement ingredient delivering L-lysine in an advanced liposomal delivery system. L-Lysine (CAS 56-87-1), also known as (2S)-2,6-diaminohexanoic acid or α,ε-diaminocaproic acid, is an essential proteinogenic α-amino acid with the molecular formula C₆H₁₄N₂O₂ and a molecular weight of 146.19 g/mol. It is a white to light yellow crystalline powder or crystals that is freely soluble in water (100 mg/mL). L-Lysine is one of the nine essential amino acids in humans and is a basic amino acid containing two amino groups and one carboxyl group.
L-Lysine is found in high-protein foods including meat, poultry, fish, dairy products, eggs, and legumes. It is particularly important as a precursor for carnitine synthesis, which is required for fatty acid transport into mitochondria for energy production. L-Lysine also plays a critical role in the biosynthesis of collagen and elastin, and enhances the absorption of calcium by the intestine, making it valuable for bone health.
Conventional L-lysine presents significant formulation challenges. Free L-lysine is extremely hygroscopic, easily deliquesces, and is susceptible to yellowing and deterioration due to its free amino groups, with a stimulating fishy smell that makes it difficult to store long-term. Additionally, L-lysine competes with other amino acids for transport across the intestinal epithelium.
Liposomal encapsulation provides four critical advantages:
1. Enhanced Stability — The phospholipid bilayer shields L-lysine from moisture absorption and oxidative degradation, preventing the yellowing and deterioration that occurs with free L-lysine. Liposomal encapsulation locks in ambient stability and significantly optimizes ingredient dispersion.
2. Enhanced Absorption and Bioavailability — Liposomal encapsulation protects L-lysine from premature metabolism in the gastrointestinal tract and facilitates efficient cellular uptake via lipid-mediated pathways. This delivery mechanism complements the amino acid transport pathways utilized by free L-lysine.
3. Sustained Release for Balanced Amino Acid Support — Liposomal delivery provides a sustained-release profile that maintains steady plasma amino acid levels, supporting balanced physiological effects rather than a sharp peak followed by rapid decline. Amino acids are best absorbed when taken half an hour before eating or sleeping.
4. Water-Dispersible Formulation — Liposomal L-lysine powder offers excellent dispersibility in water, forming a uniform suspension suitable for functional beverages and liquid formulations.
| Field | Details |
|---|---|
| Product Name | Liposomal L-Lysine 80% |
| CAS No. | 56-87-1 |
| Active Ingredient | L-Lysine |
| Assay Method | RP-HPLC with C18 column and gradient elution of phosphate buffer (pH 7.4, 10 mM) and organic modifier; UV detection at 225 nm without derivatization. Alternative: ion-pair reversed-phase HPLC with 10 mM potassium dihydrogen phosphate and 5 mM sodium 1-heptanesulfonate (ion-pairing reagent) at pH 2.5; or titration with perchloric acid for assay 97.0%–103.0% on dried basis |
| Purity | ≥ 80% L-lysine; pharmaceutical grade available with assay 97.0%–103.0% on anhydrous basis |
| Appearance / Color | White to light yellow crystalline powder or crystals |
| Odor | Odorless |
| Dosage Form | Liposomal powder, water-dispersible |
| Recommended Dosage | 500–3,000 mg per day; clinical studies have used 1,000–3,000 mg/day for cold sore management |
| Application | Immune support, cold sore (herpes simplex) management, collagen formation, calcium absorption, bone health, protein synthesis, Energy Metabolism |
| Extract Source | Fermentation-derived (Corynebacterium glutamicum or Brevibacterium species); sunflower phospholipid liposomal carrier system |
| Molecular Formula | C₆H₁₄N₂O₂ |
| Molecular Weight | 146.19 g/mol |
| Lead Time | In stock: 3–5 business days; Bulk/custom orders: 2–3 weeks |
| Shipping Method | International Express (FedEx / DHL / UPS); air and sea freight available; worldwide shipping including remote areas |
| Storage | Store in a cool, dry place away from direct sunlight and moisture; keep container tightly sealed. Shelf life: 24 months |
| Packaging | 1 kg/aluminum foil bag with two plastic bags inside; 25 kg/carton or fiber drum with aluminum foil bag inside |
High Purity — Standardized to ≥80% L-lysine, with pharmaceutical-grade assay of 97.0%–103.0% on anhydrous basis available.
Liposomal Enhancement — Phospholipid bilayer encapsulation protects L-lysine from moisture absorption and oxidative degradation, enhancing stability and intestinal absorption through lipid-mediated pathways.
Immune Support — L-Lysine helps reduce the recurrence of herpes simplex virus (HSV) infection, including cold sores. It may slow or stop the growth of viruses and protect against sexual transmission of the herpes virus.
Collagen Formation — L-Lysine is essential for the biosynthesis of collagen and elastin, supporting skin, joint, and connective tissue health.
Calcium Absorption — L-Lysine enhances intestinal calcium absorption, contributing to bone health and the treatment of osteoporosis.
Clinically Studied for Morbidity Reduction — Supplementation in children reduced diarrheal episodes, and men had fewer coryza episodes in a Ghana study.
Water-Dispersible — Freely soluble in water (100 mg/mL); suitable for capsules, tablets, powder drink mixes, and functional beverages.
Batch Traceability — Complete COA, HPLC chromatogram, and identity data provided for each batch.
| Application | Recommended Usage | Notes |
|---|---|---|
| Capsules / Tablets | 500–1,000 mg per serving | 1–3 tablets daily, best taken half an hour before eating or sleeping |
| Functional Beverages | 250–500 mg per 250 mL | Water-soluble; suitable for RTD formats |
| Powdered Drink Mixes | 500–3,000 mg per sachet | For cold sore prevention, 1,000–3,000 mg daily is commonly used |
| Immune Support Formulas | 1,000–3,000 mg per serving | Clinical studies used 1,000–3,000 mg/day for recurrent herpes simplex |
| Bone Health Formulas | 500–1,500 mg per serving | Often combined with calcium and vitamin D for synergistic bone support |
Clinical studies and commercial products commonly recommend 500–3,000 mg of L-lysine per day, depending on the intended use. For general health support, 500–1,500 mg daily is commonly recommended. Doctors often suggest that people with recurrent herpes simplex infections take 1,000–3,000 mg of lysine per day. The optimal dosage of L-lysine for prophylaxis against relapsing herpes simplex is not yet well defined, with doses ranging between 500 and 3,000 mg daily. The World Health Organization recommends approximately 30 mg per kilogram of body weight daily for lysine intake from all sources. Amino acids are best absorbed when taken half an hour before eating or sleeping. Liposomal formulations may allow for more efficient utilization of lower doses due to enhanced bioavailability.
Stock Orders: 3–5 business days after payment confirmation.
Bulk / Custom Orders: 2–3 weeks, depending on quantity and customization requirements.
Shipping Methods: International Express (FedEx, DHL, UPS), air freight, and sea freight.
Coverage: Worldwide shipping, including remote areas.
L-Lysine Encyclopedia — Scientific Background
L-Lysine (CAS 56-87-1), also known as (2S)-2,6-diaminohexanoic acid or α,ε-diaminocaproic acid, is an essential proteinogenic α-amino acid with the molecular formula C₆H₁₄N₂O₂ and a molecular weight of 146.19 g/mol. It is a white to light yellow crystalline powder or crystals that is freely soluble in water (100 mg/mL). L-Lysine is one of the nine essential amino acids in humans and is a basic amino acid containing two amino groups and one carboxyl group.
| Property | Value |
|---|---|
| CAS No. | 56-87-1 |
| Molecular Formula | C₆H₁₄N₂O₂ |
| Molecular Weight | 146.19 g/mol |
| IUPAC Name | (2S)-2,6-Diaminohexanoic acid |
| Appearance | White to light yellow crystalline powder or crystals |
| Solubility | Freely soluble in water (100 mg/mL) |
| pI | 9.47 |
| pKa | 2.16 (COOH), 9.06 (α-NH₂), 10.54 (ε-NH₂) |
L-Lysine is an essential amino acid with several critical physiological roles:
Protein Synthesis — As a proteinogenic amino acid, L-lysine is a fundamental building block for protein synthesis.
Collagen and Elastin Formation — L-Lysine helps in the biosynthesis of collagen and elastin, supporting skin, joint, and connective tissue health.
Calcium Absorption — L-Lysine increases the absorption of calcium by the intestine and is recommended for the treatment of osteoporosis.
carnitine Precursor — L-Lysine is a precursor for carnitine synthesis, which is required for fatty acid transport into mitochondria for energy production.
Immune Function — L-Lysine may slow or stop the growth of viruses and protect against sexual transmission of the herpes virus.
Hormone Production — Lysine plays an important role in the production of hormones.
Bone Development — As an essential building block for all protein, L-lysine is needed for proper growth and bone development in children.
L-Lysine's primary mechanism for cold sore management involves its antagonistic relationship with L-arginine. Both amino acids compete for transport across cell membranes and for incorporation into viral proteins. Herpes simplex virus requires arginine for replication, while lysine acts as an antagonist. By increasing lysine intake and reducing arginine-rich foods, lysine supplementation may help reduce the recurrence of herpes simplex virus infections and decrease the severity and healing time during virus reactivations.
L-Lysine is essential for the biosynthesis of collagen and elastin, the structural proteins that provide strength and elasticity to skin, blood vessels, and connective tissues. Lysine residues undergo enzymatic hydroxylation and subsequent cross-linking, which is critical for collagen stability and function.
L-Lysine enhances intestinal calcium absorption, which is important for bone health. It may improve how calcium is used and aid in bone growth and healing. This makes L-lysine valuable in the prevention and management of osteoporosis.
L-Lysine may also prevent fatigue and increase stress tolerance, supporting overall immune function and well-being.
Despite its essential physiological functions, native L-lysine presents significant formulation challenges. Free L-lysine is extremely hygroscopic, easily deliquesces, and is susceptible to yellowing and deterioration due to its free amino groups, with a stimulating fishy smell that makes it difficult to store long-term. Additionally, L-lysine competes with other amino acids for transport across the intestinal epithelium.
liposomal encapsulation addresses these limitations through a phospholipid bilayer that protects L-lysine from moisture absorption and oxidative degradation, and enhances intestinal absorption through lipid-mediated pathways. Liposomal L-lysine locks in ambient stability and significantly optimizes ingredient dispersion and bioavailability.
Liposomal encapsulation of L-lysine provides a fundamentally different delivery mechanism from conventional forms. The phospholipid bilayer surrounds the L-lysine molecule, forming a protective shell that enhances stability, absorption, and cellular uptake. This delivery system:
Protects L-lysine from moisture absorption, yellowing, and oxidative degradation
Enhances intestinal absorption through lipid-mediated pathways
Provides sustained release for prolonged amino acid availability
Enhances water dispersibility for use in aqueous formulations
L-Lysine supplementation may help reduce cold sore lesions in patients with recurrent outbreaks. Lysine is effective as a daily preventive agent in reducing HSV recurrence and as a therapeutic treatment to decrease the severity and healing time during virus reactivations. The optimal dosage of L-lysine for prophylaxis against relapsing herpes simplex is not yet well defined, with doses ranging between 500 and 3,000 mg daily.
A study comparing lysine supplementation with placebo was examined in two groups of men, women, and children (n = 271). Supplementation in children reduced diarrheal episodes, and men had fewer coryza episodes. Serum ferritin and C-reactive protein decreased in lysine-supplemented women but increased in placebo-supplemented women. Lysine supplementation reduced diarrheal morbidity in children and respiratory morbidity in men in Ghana.
L-Lysine helps in the biosynthesis of collagen and elastin as well as increases the absorption of calcium by the intestine, being recommended for the treatment of osteoporosis. It may improve how calcium is used and aid in bone growth and healing.
L-Lysine is generally well tolerated at commonly used doses. It is an essential amino acid, and its safety profile is well established. L-Lysine is widely commercialized as a dietary supplement ingredient and food additive.
Regulatory status varies by region:
United States — L-Lysine is regulated as a dietary supplement ingredient and is Generally Recognized As Safe (GRAS) for use in food and dietary supplements.
European Union — L-Lysine is permitted as a food supplement ingredient in EU member states.
Global Standards — L-Lysine is monographed in the USP, European Pharmacopoeia, and Japanese Pharmacopoeia.
L-Lysine hydrochloride contains not less than 98.5% and not more than 101.5% of l-lysine hydrochloride (C₆H₁₄N₂O₂·HCl), calculated with respect to the dried substance. Testing protocols must adhere to international standards including USP, European Pharmacopoeia, and FAO/WHO Codex Alimentarius. Formulators should verify local regulatory requirements prior to market entry.
This product is intended for research, nutraceutical, and functional food applications. Not intended to diagnose, treat, cure, or prevent any disease.
95$/KG
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