89$/KG
Product Detailed Description
liposomal L-Leucine 80% is a premium-grade dietary supplement ingredient delivering L-leucine in an advanced liposomal delivery system. L-Leucine (CAS 61-90-5), also known as L-2-amino-4-methylpentanoic acid or (S)-2-amino-4-methylpentanoic acid, is an essential branched-chain amino acid with the molecular formula C₆H₁₃NO₂ and a molecular weight of 131.17 g/mol. It occurs as white to off-white crystals or crystalline powder or shiny flakes. L-Leucine is a hydrophobic amino acid and is one of the three branched-chain amino acids (BCAAs), along with isoleucine and valine. It is the most abundant amino acid in food proteins and tissues, with the most important food sources being soybean, beef, peanuts, fish, wheat germ, almonds, chicken, eggs, and oats.
L-Leucine is classified as an essential amino acid because the human body cannot synthesize it, requiring dietary intake. L-Leucine is absorbed in the small intestine in its free form or as part of peptides and is transported to the liver, where a portion is used for protein synthesis and the rest is distributed to body tissues. Most L-leucine metabolism occurs in muscular tissue, where it undergoes reversible transamination to alpha-ketoisocaproate, followed by irreversible oxidative decarboxylation to isovaleryl-CoA and acyl-CoA derivatives, ultimately producing acetoacetate and acetyl-CoA for Energy Metabolism.
Conventional L-leucine presents significant absorption challenges. Anabolic resistance is a well-established phenomenon during aging, with cells becoming more resistant to turning on protein synthesis, and research indicates that older adults need twice as much leucine compared to younger adults for similar activation of MPS. This increased leucine requirement can be partially explained by increased retention of orally ingested leucine in the gut, which is retained twice as much compared to young adults, limiting the amount of leucine that makes it into the bloodstream.
Liposomal encapsulation provides four critical advantages:
1. Enhanced Absorption and Bioavailability — Liposomal L-leucine delivers superior bioavailability to support muscle protein synthesis, recovery, and performance. Lipoamino acids are encapsulated in liposomes, allowing for superior bioavailability compared to standard amino acids, ensuring more of the active nutrient reaches the bloodstream and cells.
2. Targeted Nutrient Delivery — Liposomal technology delivers amino acids directly into cells, improving their effectiveness in muscle repair, recovery, and protein synthesis.
3. Protection from Gastrointestinal Degradation — Unlike some free-form amino acids, lipoamino acids reduce the risk of stomach irritation or degradation in the GI tract, making them suitable for sensitive users. The phospholipid bilayer shields L-leucine from premature metabolism in the gastrointestinal tract, preserving its intact structure until reaching optimal absorption sites.
4. Sustained Release and Formulation Stability — Lipoamino acids offer greater formulation stability, making them ideal for use in powders, capsules, liquid sachets, and functional beverages. Liposomal delivery provides a sustained-release profile that maintains steady plasma amino acid levels, supporting prolonged mTOR activation and protein synthesis.
High Purity — Standardized to ≥80% L-leucine, with pharmaceutical-grade assay of 98.5%–101.0% on anhydrous basis available.
Liposomal Enhancement — Liposomal encapsulation delivers superior bioavailability to support muscle protein synthesis, recovery, and performance.
Potent mTOR Activator — L-Leucine is the most potent activator of protein synthesis among all amino acids. Cells sense leucine levels and respond by turning on protein synthesis via mTOR, a master-regulator of protein synthesis.
Clinically Studied for Muscle Protein Synthesis — Leucine supplementation of a low-protein (6.25 g) mixed macronutrient beverage can be as effective as a high-protein dose (25 g) at stimulating increased MPS rates when supplemented with a high (5.0 g total leucine) amount of leucine.
Sarcopenia and Aging Support — Anabolic resistance during aging can be partly ameliorated with extra leucine, as research indicates that older adults need twice as much leucine compared to younger adults for similar activation of MPS.
Metabolic Regulation — L-Leucine stimulates protein synthesis, controls satiety by acting directly on the hypothalamus and stimulating leptin release, controls body weight by reducing fatty mass, controls energy expenditure, and improves glucose metabolism and sensitivity.
GRAS and FDA Affirmed — L-Leucine is a food additive (E 641) authorized in the European Union with assay specification of 98.5%–101.0% on the anhydrous basis.
Water-Dispersible — Suitable for capsules, tablets, powder drink mixes, and functional beverages.
Batch Traceability — Complete COA, HPLC chromatogram, and identity data provided for each batch.
Clinical studies and commercial products commonly recommend varying doses of L-leucine depending on the application. The standard leucine dosage is 2–10 grams, with leucine tending to be supplemented in the 2,000–5,000 mg range for acute usage. The AESAN has recommended a maximum daily amount of 2,950 mg of L-leucine in food supplements. In accordance with the FAO/WHO/UNU joint technical report, the requirements for L-leucine in adults are 39 mg/kg body weight per day. The usual daily intake of L-leucine in the Western population is between 6 and 9 g per person per day, although male adults between 50–70 years old may take up to 14 g/day. L-Leucine is best absorbed when taken between meals or in a fasted state, or alongside meals with inherently low protein content. Liposomal formulations may allow for more efficient utilization of lower doses due to enhanced bioavailability.
Stock Orders: 3–5 business days after payment confirmation.
Bulk / Custom Orders: 2–3 weeks, depending on quantity and customization requirements.
Shipping Methods: International Express (FedEx, DHL, UPS), air freight, and sea freight.
Coverage: Worldwide shipping, including remote areas.
L-Leucine Encyclopedia — Scientific Background
L-Leucine (CAS 61-90-5), also known as L-2-amino-4-methylpentanoic acid or (S)-2-amino-4-methylpentanoic acid, is an essential branched-chain amino acid with the molecular formula C₆H₁₃NO₂ and a molecular weight of 131.17 g/mol. It occurs as white to off-white crystals or crystalline powder or shiny flakes. L-Leucine is a hydrophobic amino acid and is one of the three branched-chain amino acids (BCAAs), along with isoleucine and valine. It is the most abundant amino acid in food proteins and tissues, with the most important food sources being soybean, beef, peanuts, fish, wheat germ, almonds, chicken, eggs, and oats.
L-Leucine is an essential amino acid with several critical physiological roles:
Protein Synthesis Activation — L-Leucine serves as a structural base for protein synthesis and is also a powerful activator of the mammalian target of rapamycin (mTOR), a serine/threonine kinase involved in numerous cellular processes.
Satiety Regulation — L-Leucine controls satiety by acting directly on the hypothalamus and stimulating the release of leptin.
Body Weight Control — L-Leucine controls body weight by reducing fatty mass.
Glucose Metabolism — L-Leucine improves the metabolism of glucose and sensitivity to insulin.
Muscle Energy Source — L-Leucine may act as a source of energy for muscle in the absence of glycogen.
L-Leucine is the most potent nutrient-based signal to activate protein synthesis. Cells are able to sense leucine levels and in response turn on protein synthesis via the enzyme mTOR, a master-regulator of protein synthesis. Leucine acutely activates mTORC1 and enhances muscle protein synthesis, and leucine elicits myotube hypertrophy and enhances maximal contractile force in tissue engineered skeletal muscle in vitro.
L-Leucine supplementation of a low-protein mixed macronutrient beverage enhances myofibrillar protein synthesis. A low-protein (6.25 g) mixed macronutrient beverage can be as effective as a high-protein dose (25 g) at stimulating increased MPS rates when supplemented with a high (5.0 g total leucine) amount of leucine.
Anabolic resistance is a well-established phenomenon during aging, with cells becoming more resistant to turning on protein synthesis. This can be partly ameliorated with extra leucine, as research indicates that older adults need twice as much leucine compared to younger adults for similar activation of MPS. This increased leucine requirement can be partially explained by increased retention of orally ingested leucine in the gut, which is retained twice as much compared to young adults, limiting the amount of leucine that makes it into the bloodstream. Resistance to leucine-stimulated protein synthesis also occurs at the cellular level in aging cells.
Despite its essential physiological functions, native L-leucine presents significant absorption challenges. Anabolic resistance during aging leads to increased retention of orally ingested leucine in the gut, limiting the amount that reaches the bloodstream. This is particularly problematic because older adults need twice as much leucine compared to younger adults for similar activation of MPS.
liposomal encapsulation addresses these limitations through a phospholipid bilayer that protects L-leucine during digestive transit and provides an alternative absorption pathway. Liposomal L-leucine delivers superior bioavailability to support muscle protein synthesis, recovery, and performance, ensuring more of the active nutrient reaches the bloodstream and cells.
Liposomal encapsulation of L-leucine provides a fundamentally different delivery mechanism from conventional forms. The phospholipid bilayer surrounds the L-leucine molecule, forming a protective shell that enhances stability, absorption, and cellular uptake. This delivery system:
Delivers superior bioavailability compared to standard amino acids
Provides targeted nutrient delivery directly into cells for improved effectiveness in muscle repair and protein synthesis
Reduces the risk of stomach irritation or degradation in the GI tract
Offers greater formulation stability for use in powders, capsules, liquid sachets, and functional beverages
Liposomal L-leucine is an ideal ingredient for high-efficiency sports and nutritional supplements, delivering superior bioavailability to support muscle protein synthesis, recovery, and performance. Key ingredients like liposomal L-Leucine, L-Isoleucine, and L-Valine promote faster muscle recovery, improved endurance, and reduced fatigue—ideal for athletic and active lifestyles.
A double-blind, randomized trial demonstrated that leucine supplementation of a low-protein (6.25 g) mixed macronutrient beverage enhances myofibrillar protein synthesis in young men. A low-protein mixed macronutrient beverage can be as effective as a high-protein dose (25 g) at stimulating increased MPS rates when supplemented with a high (5.0 g total leucine) amount of leucine. Results in both younger and older adults have shown that supplementation with leucine enhances the MPS response, namely when a suboptimal dose of protein is consumed.
A 4-day randomized controlled trial examined the effect of increased protein intake derived from leucine-enriched protein on the integrated myofibrillar protein synthetic response to short-term resistance training in untrained men and women. Studies have demonstrated that leucine supplementation of a low-protein beverage enhances myofibrillar protein synthesis, and leucine elicits myotube hypertrophy and enhances maximal contractile force in tissue engineered skeletal muscle in vitro.
Key ingredients like liposomal L-Leucine, L-Isoleucine, and L-Valine promote faster muscle recovery, improved endurance, and reduced fatigue, making them ideal for athletic and active lifestyles. Lipoamino acids are encapsulated in liposomes, allowing for superior bioavailability compared to standard amino acids.
L-Leucine stimulates protein synthesis, controls satiety by acting directly on the hypothalamus and stimulating leptin release, controls body weight by reducing fatty mass, controls energy expenditure, and improves glucose metabolism and sensitivity. These metabolic functions depend on its intracellular concentration and support its role in comprehensive metabolic health management.
L-Leucine is generally well tolerated at commonly used doses. Mammals have a high capacity for metabolizing L-leucine, with a maximum oxidation level of 8.9 g/kg body weight per day. In the European Union, L-Leucine is authorized as a food additive (E 641) with a specification of content not less than 98.5% and not more than 101.0% on the anhydrous basis. The AESAN has recommended a maximum daily amount of 2,950 mg of L-leucine in food supplements. In Italy, a maximum daily amount of 1,330 mg of L-leucine is authorized in food supplements, and in Belgium, L-leucine is authorized in food supplements without establishing a maximum daily amount.
Regulatory status varies by region:
United States — L-Leucine is regulated as a dietary supplement ingredient and is Generally Recognized As Safe (GRAS) for use in food and dietary supplements.
European Union — L-Leucine is authorized as food additive E 641 in accordance with Regulation (EU) No 231/2012.
Global Standards — L-Leucine is monographed in the USP, European Pharmacopoeia, Japanese Pharmacopoeia (JP), British Pharmacopoeia (BP), and Food Chemicals Codex (FCC).
Testing protocols must adhere to international standards including USP, European Pharmacopoeia, and FAO/WHO Codex Alimentarius. Formulators should verify local regulatory requirements prior to market entry.
This product is intended for research, nutraceutical, and functional food applications. Not intended to diagnose, treat, cure, or prevent any disease.
89$/KG
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