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Liposomal dihydromyricetin

Liposomal dihydromyricetin is an advanced delivery form of dihydromyricetin, a naturally occurring flavonoid compound found in several plant sources. In its conventional form, dihydromyricetin has attracted attention for its potential biological activity, but its practical use can be limited by poor water solubility, low stability, and relatively low absorption in the human body. To address these challenges, researchers and formulators have explored liposomal encapsulation as an effective way to improve its performance. By enclosing dihydromyricetin within phospholipid-based vesicles, the liposomal form can enhance dispersibility, protect the active ingredient from environmental degradation, and support better uptake in biological systems.Liposomal dihydromyricetin is typically composed of one or more phospholipid bilayers surrounding an aqueous core, with the active compound embedded within or associated with the lipid structure. This design can help shield dihydromyricetin from oxidation, light, heat, and other factors that may reduce its potency over time. The liposomal carrier also offers the possibility of improved bioavailability, since liposomes can interact more readily with biological membranes and facilitate transport of the encapsulated compound.From a formulation perspective, liposomal delivery is often chosen for compounds that are difficult to dissolve or absorb. Dihydromyricetin fits this profile well, making it a suitable candidate for liposomal technology. The resulting product may be easier to incorporate into oral liquids, capsules, functional beverages, or other dosage forms depending on the intended application. In addition, liposomal systems can sometimes provide more controlled release characteristics, allowing the active ingredient to be delivered more gradually than in a non-encapsulated form.Interest in dihydromyricetin itself has grown because of its association with antioxidant and protective properties in laboratory and preclinical research. While these findings are still being explored and should not be interpreted as medical claims, they have contributed to the popularity of the compound in nutraceutical and wellness-related product development. Liposomal technology adds an extra layer of formulation sophistication, making the ingredient more attractive for modern delivery systems that prioritize stability and absorption.Quality considerations are important for liposomal dihydromyricetin products. Factors such as particle size, encapsulation efficiency, lipid composition, and storage conditions can influence performance. A well-designed liposomal product should maintain good physical stability, consistent dispersibility, and reliable active ingredient content throughout its shelf life. Manufacturing methods may include thin-film hydration, ethanol injection, high-pressure homogenization, or other techniques optimized to create uniform vesicles.Overall, liposomal dihydromyricetin represents a promising approach to enhancing the practical use of a valuable plant-derived flavonoid. By combining the biological interest of dihydromyricetin with the delivery advantages of liposomal encapsulation, this form aims to improve stability, absorption, and versatility in formulation. It is an example of how modern delivery science can help address long-standing limitations of natural compounds and expand their potential applications.

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  • Liposomal Dihydromyricetin 70% High Bioavailability Liver Protection and Antioxidant Supplement

    Liposomal Dihydromyricetin 70% High Bioavailability Liver Protection and Antioxidant Supplement

    Category: Others
    Browse number: 145
    Number:
    Release time: 2026-10-20 19:13:52
    Product Summary Liposomal Dihydromyricetin 70% is a high-purity, liposomal-encapsulated form of dihydromyricetin (DHM)—the principal bioactive flavanonol extracted from vine tea (Ampelopsis grossedentata), a traditional Chinese medicinal and edible herb consumed for over 600 years—standardized to ≥70% active content. DHM is a dietary flavonoid recognized for its potent antioxidant, anti-inflammatory, and hepatoprotective properties, with specific research demonstrating significant anti-alcohol effects through negative allosteric modulation of GABA_A receptors and acceleration of alcohol metabolism via enhanced activities of alcohol-metabolizing enzymes (ADH and ALDH). However, native DHM exhibits extremely low absolute bioavailability of only 4.02% in rats due to its poor water solubility, low intestinal permeability, and susceptibility to degradation by gastric acid. Liposomal encapsulation within a phospholipid bilayer addresses these fundamental limitations. A novel liposomal formulation (DHM-Lipo-Rg3) achieved >95% encapsulation efficiency with particle size <90 nm and significantly improved bioavailability by 3.1-fold in males and 5.4-fold in females in pharmacokinetic studies. Another cyclodextrin-liposome system demonstrated 5.83-fold and 3.38-fold increases in AUC₀–₉₀ₘᵢₙ and Cmax, respectively. This water-dispersible powder is suitable for capsules, functional beverages, and nutritional formulations targeting liver protection, alcohol metabolism support, and antioxidant defense. Each batch is HPLC-standardized and quality-tested for purity, identity, and DHM content.

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