429$/KG
329$/KG
Product Detailed Description
liposomal Pterostilbene 70% is a premium-grade dietary supplement ingredient delivering trans-pterostilbene in an advanced liposomal delivery system. Pterostilbene (CAS 537-42-8), also known as 3,5-dimethoxy-4′-hydroxystilbene or 3′,5′-dimethoxy-RESVERATROL, is a naturally occurring stilbenoid compound with the molecular formula C₁₆H₁₆O₃ and a molecular weight of 256.30 g/mol. It is a dimethylated analog of resveratrol, in which two methoxy groups on the pterostilbene molecule replace hydroxy groups on the resveratrol molecule. This structural modification significantly enhances its lipophilicity, membrane permeability, and metabolic stability compared to resveratrol.
Pterostilbene is found in various natural plant sources including blueberries, grapes, peanuts, and plants widely used in traditional medicine such as Pterocarpus marsupium and Vitis vinifera leaves. It was first isolated in 1940 from the heartwood of red sandalwood (Pterocarpus santalinus). Pterostilbene is synthesized in plants as a secondary metabolite in response to environmental stress or fungal infections. The compound is recognized for its potent antioxidant, anti-inflammatory, anticancer, and anti-aging properties.
Conventional pterostilbene, while already offering superior bioavailability compared to resveratrol, presents formulation challenges. Pterostilbene is a lipid-soluble polyphenol with low water solubility, which limits its dispersibility in aqueous systems. Its application is further restricted by poor penetration through biological barriers such as the stratum corneum.
Liposomal encapsulation provides four critical advantages:
1. Significantly Enhanced Retention and Bioavailability — Pterostilbene nanoliposomes (PT-NLPs) prepared using high shear-microjet homogenization treatment demonstrated a 1.7-fold increase in retention performance compared with free pterostilbene solution. This enhanced retention translates directly into improved bioavailability and prolonged biological activity.
2. Enhanced Stability and Protection — The phospholipid bilayer shields pterostilbene from premature degradation during digestive transit and protects it from light, oxidation, and pH changes. Liposomal encapsulation prevents the active ingredient from being destroyed by gastric acid and digestive enzymes.
3. Enhanced Aqueous Dispersibility — Liposomal encapsulation transforms the poorly water-soluble pterostilbene into a water-dispersible powder that forms a uniform dispersion in aqueous systems, enabling incorporation into functional beverages, liquid supplements, and other aqueous formulations.
4. Enhanced Cellular Uptake and Targeted Delivery — Liposomes fuse directly with cell membranes, facilitating efficient cellular delivery via lipid-mediated pathways. Liposomal technology can deliver nutrients more precisely to the tissues that need repair or supplementation, reducing loss and improving utilization efficiency.
High Purity — Standardized to ≥70% pterostilbene loading by weight relative to the total formulation, ensuring consistent active content.
Liposomal Enhancement — Phospholipid bilayer encapsulation achieves a 1.7-fold increase in retention performance compared with free pterostilbene solution, enhancing bioavailability and prolonging biological activity.
Superior Bioavailability vs. Resveratrol — Pterostilbene is much better absorbed following oral ingestion than resveratrol and may be a more potent antioxidant and anticancer molecule.
SIRT1 Pathway Activation — Pterostilbene is more bioavailable than resveratrol and effectively activates SIRT1 “longevity” pathways.
Cognitive and Neuroprotective Support — Pterostilbene crosses the blood-brain barrier more efficiently than resveratrol to support brain cell health and memory.
Metabolic Health Support — Helps maintain healthy blood sugar and lipid levels through optimized cellular energy pathways.
Superior Antioxidant Activity — Neutralizes oxidative stress with a higher cellular retention rate than non-methylated polyphenols.
Cellular Vitality Support — Boosts mitochondrial function and reduces age-related cellular fatigue.
Water-Dispersible — Liposomal powder offers excellent dispersibility in aqueous systems; suitable for capsules, tablets, powder drink mixes, and functional beverages.
Batch Traceability — Complete COA, HPLC chromatogram, and identity data provided for each batch.
| Application | Recommended Usage | Notes |
|---|---|---|
| Capsules / Tablets | 50–125 mg per serving | 1–2 capsules daily with meals; human studies used 50–125 mg twice daily |
| Functional Beverages | 25–50 mg per 250 mL | Water-dispersible; suitable for RTD formats |
| Powdered Drink Mixes | 50–250 mg per sachet | Best absorbed when taken with food containing fat |
| Longevity / Anti-Aging Formulas | 50–250 mg per serving | Often combined with NAD+ precursors or resveratrol |
| Cognitive Support Formulas | 50–125 mg per serving | Often combined with omega-3 fatty acids or curcumin |
| Metabolic Support Formulas | 50–125 mg per serving | Often combined with Berberine or chromium |
Clinical studies and commercial products commonly recommend varying doses of pterostilbene depending on the application. Limited human studies have used either 50 mg twice a day or 125 mg twice a day, and the addition of grape seed extract (100 mg at both dosing times) with the low dose may mitigate some adverse effects on cholesterol seen with pterostilbene in isolation. For the purpose of aiding glucose and lipid metabolism, estimated human dosage ranges based on rat studies are 215–430 mg for a 150 lb person, 290–580 mg for a 200 lb person, and 365–730 mg for a 250 lb person. Available human supplementation data suggest that pterostilbene is generally well tolerated at doses of up to 250 mg/day for 8 weeks. For general antioxidant and longevity support, 50–125 mg daily is commonly used. Liposomal formulations may allow for more efficient utilization of lower doses due to enhanced bioavailability.
Important Safety Information: Pterostilbene is generally well tolerated. One human study found an increase in LDL-cholesterol and a trend towards decreased HDL in people with high cholesterol levels who took 100 or 250 mg per day. Although 100 mg/day pterostilbene failed to have significant effects on blood pressure, blood pressure decreased on average by −8 mmHg systolic and −7 mmHg diastolic in the group who took the higher 250 mg/day dose. Individuals with high cholesterol should monitor lipid profiles and consult a healthcare professional before use. Pregnant or lactating women and children should consult a healthcare professional before use.
Stock Orders: 3–5 business days after payment confirmation.
Bulk / Custom Orders: 2–3 weeks, depending on quantity and customization requirements.
Shipping Methods: International Express (FedEx, DHL, UPS), air freight, and sea freight.
Coverage: Worldwide shipping, including remote areas.
Pterostilbene Encyclopedia — Scientific Background
Pterostilbene (CAS 537-42-8), also known as 3,5-dimethoxy-4′-hydroxystilbene or 3′,5′-dimethoxy-RESVERATROL, is a naturally occurring stilbenoid compound with the molecular formula C₁₆H₁₆O₃ and a molecular weight of 256.30 g/mol. It is a stilbenol that consists of trans-stilbene bearing a hydroxy group at position 4 as well as two methoxy substituents at positions 3′ and 5′. Pterostilbene is a dimethylated analog of resveratrol, in which two methoxy groups replace hydroxy groups on the resveratrol molecule.
| Property | Value |
|---|---|
| CAS No. | 537-42-8 |
| Molecular Formula | C₁₆H₁₆O₃ |
| Molecular Weight | 256.30 g/mol |
| IUPAC Name | 4-[(E)-2-(3,5-Dimethoxyphenyl)ethenyl]phenol |
| Synonyms | 3,5-Dimethoxy-4′-hydroxystilbene, 3′,5′-Dimethoxy-resveratrol, Trans-pterostilbene |
| Appearance | Off-white to yellow powder (native form); white powder (liposomal form) |
| Solubility | 0.0180 mg/g in water; 1127 mg/g in propylene glycol; 710.0 mg/g in ethanol; 340.0 mg/g in PEG-400 |
| Melting Point | 89–92°C |
| LogP | 4.12 |
| Purity (Standard) | ≥98% (HPLC) for research-grade material |
Pterostilbene is found in various natural plant sources including:
Blueberries — A primary dietary source of pterostilbene
Grapevines (Vitis vinifera) — Contains pterostilbene in leaves and fruits
Red Sandalwood (Pterocarpus santalinus) — The heartwood was the first identified source, where pterostilbene was isolated in 1940
Peanuts — A dietary source of pterostilbene
Pterocarpus marsupium — A plant widely used in traditional medicine
Pterostilbene is synthesized in plants as a secondary metabolite in response to environmental stress or fungal infections.
Pterostilbene is more bioavailable than resveratrol and effectively activates SIRT1 “longevity” pathways. SIRT1 is an NAD⁺-dependent deacetylase that regulates gene expression, DNA repair, and cellular stress responses, and its activation is associated with improved metabolic function and longevity-related pathways.
Pterostilbene neutralizes oxidative stress with a higher cellular retention rate than non-methylated polyphenols. The two methoxy groups on the pterostilbene molecule enhance its lipophilicity, facilitating more efficient incorporation into cellular membranes and prolonged antioxidant activity compared to resveratrol.
Pterostilbene crosses the blood-brain barrier more efficiently than resveratrol to support brain cell health and memory. Its enhanced lipophilicity and membrane permeability enable superior central nervous system delivery compared to other stilbenoids.
Pterostilbene helps maintain healthy blood sugar and lipid levels through optimized cellular energy pathways. It boosts mitochondrial function and reduces age-related cellular fatigue.
Pterostilbene demonstrates significant antioxidant, antimicrobial, and anti-inflammatory properties. These activities contribute to its broad therapeutic potential for various disease conditions.
Despite its promising therapeutic potential, native pterostilbene presents significant formulation challenges. Pterostilbene is a lipid-soluble polyphenol with low water solubility (0.0180 mg/g in water), which limits its dispersibility in aqueous systems and its absorption following oral administration. Its application is further restricted by poor penetration through biological barriers such as the stratum corneum.
These limitations have driven the development of advanced delivery systems, including liposomal encapsulation. Pterostilbene nanoliposomes prepared by high shear-microjet homogenization treatment demonstrated a 1.7-fold increase in retention performance compared with free pterostilbene solution, with no penetration across the blood-brain barrier observed in safety testing.
Liposomal encapsulation of pterostilbene provides a fundamentally different delivery mechanism from conventional forms. The phospholipid bilayer surrounds the pterostilbene molecule, forming a protective shell that enhances solubility, stability, and cellular uptake. This delivery system:
Achieves a 1.7-fold increase in retention performance compared with free pterostilbene solution
Protects pterostilbene from premature degradation during digestive transit
Enhances aqueous dispersibility for use in functional beverages and liquid formulations
Provides targeted delivery to tissues requiring repair or supplementation
Reduces loss and improves utilization efficiency
The phospholipid layer acts as a “protective shell,” effectively preventing active ingredients from degrading due to light, oxidation, or pH changes, while also enabling a slow release within the body to extend the duration of effectiveness.
Only one study has evaluated pterostilbene in humans. It found an increase in LDL-cholesterol and a trend towards decreased HDL in people with high cholesterol levels who took 100 or 250 mg per day. Although 100 mg/day pterostilbene failed to have significant effects on blood pressure, blood pressure decreased on average by −8 mmHg systolic and −7 mmHg diastolic in the group who took the higher 250 mg/day dose.
Available human supplementation data suggest that pterostilbene is generally well tolerated at doses of up to 250 mg/day for 8 weeks. No serious adverse effects have been reported at these doses in human studies.
Pterostilbene has been investigated for its potential in cardiovascular applications, including inhibition of LDL oxidation, and exhibits potent antioxidant and anti-inflammatory properties. Preclinical studies have demonstrated its ability to support metabolic health through optimized cellular energy pathways.
A comprehensive study on pterostilbene nanoliposomes for cosmetic applications found that a PT-NLPs whitening serum could improve skin dullness, brighten skin tone, and improve skin sensitivity after 14 days of use. The high shear-microjet homogenization method improved the transdermal delivery properties of pterostilbene, demonstrating broad application prospects in medicine and cosmetics.
Pterostilbene is generally well tolerated at commonly used doses. Available human supplementation data suggest that pterostilbene is generally well tolerated at doses of up to 250 mg/day for 8 weeks. One human study found an increase in LDL-cholesterol and a trend towards decreased HDL in people with high cholesterol levels who took 100 or 250 mg per day, suggesting that individuals with high cholesterol should monitor lipid profiles.
Regulatory status varies by region:
United States — Pterostilbene is regulated as a dietary supplement ingredient. It is available as a research chemical with ≥98% purity and is commercialized in dietary supplement products.
European Union — Pterostilbene is used as a cosmetic ingredient and dietary supplement ingredient in EU member states.
Global Standards — Pterostilbene is available with purity specifications of ≥98% (HPLC) for research-grade material and ≥97% for cosmetic-grade material. The compound is monographed in the Chemical Entities of Biological Interest (ChEBI) ontology (CHEBI:8630) and is listed in the FDA Global Substance Registration System.
Precautions: Individuals with high cholesterol should monitor lipid profiles and consult a healthcare professional before use, as one human study found an increase in LDL-cholesterol. Pregnant or lactating women and children should consult a healthcare professional before use. The long-term safety of high-dose pterostilbene supplementation has not been fully established.
Testing protocols must adhere to international standards including USP, European Pharmacopoeia, and FAO/WHO Codex Alimentarius. Formulators should verify local regulatory requirements prior to market entry.
This product is intended for research, nutraceutical, and functional food applications. Not intended to diagnose, treat, cure, or prevent any disease.
429$/KG
329$/KG
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