69$/KG
Product Detailed Description
liposomal Magnesium Sulfate 80% is a premium-grade dietary supplement ingredient delivering magnesium sulfate in an advanced liposomal delivery system. Magnesium sulfate (MgSO₄), commonly known as Epsom salt, is an inorganic salt composed of magnesium cations (Mg²⁺) and sulfate anions (SO₄²⁻). It occurs as colorless crystals or a white powder that is freely soluble in water. The anhydrous form (CAS 7487-88-9) has a molecular weight of 120.37 g/mol, while the heptahydrate form (CAS 10034-99-8) has a molecular weight of 246.47 g/mol.
Magnesium is an essential mineral that plays a critical role in neurochemical transmission and muscular excitability. It is required by all enzymatic processes involving ATP and is essential for maintaining normal bone density, cardiac rhythmicity, pulmonary function, and blood glucose regulation. Magnesium deficiency is one of the most common worldwide deficiencies and is associated with a wide range of physiological dysfunctions.
Conventional magnesium sulfate, while effective as an electrolyte replenisher when administered parenterally, presents significant limitations for oral supplementation. It is poorly absorbed from the gastrointestinal tract and acts primarily as an osmotic laxative, drawing water into the intestines and causing diarrhea. This limits its utility for systemic magnesium replenishment.
Conventional oral magnesium sulfate is poorly absorbed and is primarily used for its laxative effect. Liposomal encapsulation provides four critical advantages:
1. Enhanced Bioavailability and Absorption — The material constituting liposomes is recognized by the human body since it is identical to the elements that make up most of the cells. Liposomes avoid digestive elements, transferring the nutrient from the digestive tract into the bloodstream and then to the targeted area, achieving bioavailability. This protects magnesium from premature interaction with gastric contents and facilitates efficient cellular delivery.
2. Transdermal Delivery Capability — Liposomal magnesium sulfate can be delivered via the skin, bypassing the digestive system entirely. Transdermal magnesium means that magnesium ions are absorbed via the epidermis, the outer layer of the skin. This delivery method avoids the laxative effect and gastrointestinal discomfort associated with oral magnesium sulfate. Liposomal creams have been shown scientifically to be readily absorbed and to produce a reliable and predictable level of delivery into the body.
3. Sustained Release — Liposomal formulations provide controlled release of magnesium, maintaining consistent active levels for prolonged physiological support. The liposomal structure allows it to easily pass through the skin tissue and release the magnesium sulfate gradually into the body.
4. Dual-Ion Delivery — Magnesium sulfate provides both magnesium and sulfate ions. Sulfate is involved in numerous physiological processes, including detoxification pathways, joint health, and the synthesis of glycosaminoglycans.
High Purity — Standardized to ≥80% magnesium sulfate, ensuring consistent active content and ≥9.8% elemental magnesium.
Liposomal Enhancement — Phospholipid bilayer encapsulation protects magnesium from gastric interaction and enhances absorption through lipid-mediated pathways.
Transdermal Delivery — Suitable for transdermal formulations that bypass the digestive system, avoiding the laxative effect of oral magnesium sulfate.
Dual-Ion Delivery — Provides both magnesium and sulfate ions for comprehensive physiological support.
Nervous System Support — Magnesium is an important cofactor for enzymatic reactions and plays a significant role in neurochemical transmission and muscular excitability.
Cardiovascular Support — Magnesium acts peripherally to produce vasodilation, with low doses causing flushing and sweating, and larger doses causing lowering of blood pressure.
Muscle Relaxation — Magnesium prevents or controls convulsions by blocking neuromuscular transmission and decreasing the amount of acetylcholine liberated at the end-plate by the motor nerve impulse.
Water-Dispersible — Suitable for capsules, tablets, powder drink mixes, transdermal creams, and functional beverages.
Batch Traceability — Complete COA, HPLC chromatogram, and identity data provided for each batch.
| Application | Recommended Usage | Notes |
|---|---|---|
| Capsules / Tablets | 100–500 mg magnesium sulfate per serving | 1–2 capsules daily with meals |
| Functional Beverages | 50–200 mg per 250 mL | Water-dispersible; suitable for RTD formats |
| Powdered Drink Mixes | 100–500 mg per sachet | Blend with other electrolytes for synergistic balance |
| Transdermal Creams | 1–10% liposomal magnesium sulfate in formulation | Provides 100 mg magnesium sulfate per gram of cream |
| Magnesium Repletion Formulas | 100–500 mg per serving | Often combined with vitamin B6 or taurine for enhanced cellular uptake |
Clinical reference guidelines for parenteral magnesium sulfate indicate a dosage range of approximately 1–50 mg/kg body weight. Transdermal formulations typically provide 100 mg magnesium sulfate per gram of cream, with a one-gram dose delivering this amount in a well-absorbed liposomal formula. For oral supplementation, magnesium sulfate is typically administered as 5–15 g for laxative purposes, but liposomal formulations are designed for systemic magnesium repletion at significantly lower doses. Liposomal formulations may allow for more efficient utilization of lower doses due to enhanced bioavailability and the option of transdermal delivery.
Stock Orders: 3–5 business days after payment confirmation.
Bulk / Custom Orders: 2–3 weeks, depending on quantity and customization requirements.
Shipping Methods: International Express (FedEx, DHL, UPS), air freight, and sea freight.
Coverage: Worldwide shipping, including remote areas.
Magnesium Sulfate Encyclopedia — Scientific Background
Magnesium sulfate (MgSO₄), commonly known as Epsom salt, is an inorganic salt composed of magnesium cations and sulfate anions. The anhydrous form has the molecular formula MgSO₄ and a molecular weight of 120.37 g/mol, while the heptahydrate form (MgSO₄·7H₂O) has a molecular weight of 246.47 g/mol and occurs as colorless crystals or a white powder that is freely soluble in water. Magnesium sulfate is chemically designated as sulfuric acid magnesium salt (1:1).
| Property | Value |
|---|---|
| CAS No. | 7487-88-9 (anhydrous); 10034-99-8 (heptahydrate) |
| Molecular Formula | MgSO₄ (anhydrous) |
| Molecular Weight | 120.37 g/mol (anhydrous); 246.47 g/mol (heptahydrate) |
| Appearance | White crystalline powder or colorless crystals |
| Solubility | Freely soluble in water |
| EINECS | 231-298-2 |
Magnesium is the fourth most plentiful cation in the body, with a total body content of about 2,000 mEq in a 70-kg man. Only 1% exists in the extracellular fluid, while 50% of total body magnesium is found in bone. Normal serum values range from 1.6 to 2.1 mEq/L (1.9 to 2.5 mg/dL).
Magnesium is required for all enzymatic processes involving ATP, including phosphatases such as ATP and alkaline phosphatase. It is required for thiamine pyrophosphate cofactor activity and appears to stabilize macromolecular structures such as DNA and RNA. Magnesium is also intimately related to calcium and potassium metabolism.
Magnesium deficiency may result in physiologic dysfunctions, with low blood concentration known as hypomagnesemia. Predominant deficiency effects are neurological, including muscle irritability, clonic twitching, and tremors.
Magnesium prevents or controls convulsions by blocking neuromuscular transmission and decreasing the amount of acetylcholine liberated at the end-plate by the motor nerve impulse. This mechanism underlies magnesium sulfate‘s clinical use as an anticonvulsant, particularly in the treatment of pre-eclampsia and eclampsia.
Magnesium acts peripherally to produce vasodilation. With low doses only flushing and sweating occur, but larger doses cause lowering of blood pressure. Magnesium sulfate may act as a vasodilator, with actions in the peripheral vasculature or the cerebrovasculature, to decrease peripheral vascular resistance or relieve vasoconstriction.
Magnesium acts via extracellular and intracellular mechanisms to decrease intracellular calcium concentrations, thereby preventing the contractile response. Magnesium sulfate is proposed to decrease uterine smooth muscle contractility by antagonistically competing with intracellular calcium.
Magnesium is said to have a depressant effect on the central nervous system (CNS). Magnesium sulfate may also protect the blood-brain barrier and limit cerebral edema formation, or it may act through a central anticonvulsant action.
Despite magnesium‘s essential physiological functions, oral magnesium sulfate presents significant absorption limitations. Conventional oral magnesium sulfate is poorly absorbed from the gastrointestinal tract and acts primarily as an osmotic laxative, drawing water into the intestines and causing diarrhea. This limits its utility for systemic magnesium replenishment.
The material which constitutes liposomes is recognized by the human body since it is identical to the elements which make up most of the cells. liposomal encapsulation addresses these limitations by protecting magnesium from premature interaction with gastric contents and enabling absorption through alternative pathways, including transdermal delivery.
Liposomal encapsulation of magnesium sulfate provides a fundamentally different delivery mechanism from conventional forms. The phospholipid bilayer surrounds the magnesium sulfate, forming a protective shell that enhances absorption and enables transdermal delivery. This delivery system:
Protects magnesium from gastric interaction and premature metabolism
Enhances intestinal absorption through lipid-mediated pathways
Enables transdermal delivery that bypasses the digestive system
Provides sustained release for prolonged physiological support
Transdermal magnesium means that magnesium ions are absorbed via the epidermis. The skin is a very large membrane and a self-regulating one, capable of absorbing electrolytes via the same channels used for sweating. This new formula is a true transdermal cream containing a special liposome with 100 bilayer lipid shells—identical to cell membrane lipids—allowing it to easily pass through the skin tissue and release the magnesium sulfate gradually into the body.
Emergency rooms routinely use magnesium sulfate before, during, and after cardiac arrest. One of the most important actions of magnesium is its vasodilating effects, improving blood flow. Magnesium sulfate is used as an anticonvulsant and electrolyte replenisher in the treatment of pre-eclampsia and eclampsia.
Magnesium uptake has been tested extensively in balneotherapy studies demonstrating superior absorption of magnesium via the skin. Transdermal absorption of minerals has been practiced for thousands of years in a process called Balneotherapy (saltwater bathing in mineral springs) to relieve arthritis and tight muscles.
Liposomal delivery offers increased bioavailability and absorption. The material constituting liposomes is recognized by the human body since it is identical to cell membrane components. Due to their very small size, liposomes avoid digestive elements, transferring the nutrient from the digestive tract into the bloodstream and then to the targeted area, achieving bioavailability.
Magnesium sulfate is generally well tolerated when used appropriately. Normal plasma magnesium levels range from 1.5 to 2.5 mEq/L. As plasma magnesium rises above 4 mEq/L, deep tendon reflexes are first decreased and then disappear as the plasma level approaches 10 mEq/L. At this level, respiratory paralysis may occur. Heart block also may occur at this or lower plasma levels. Serum magnesium concentrations in excess of 12 mEq/L may be fatal. The central and peripheral effects of magnesium poisoning are antagonized to some extent by intravenous administration of calcium.
Magnesium sulfate is widely commercialized as a dietary supplement ingredient, pharmaceutical agent, and cosmetic ingredient. It is generally recognized as safe (GRAS) for use in food and dietary supplements. Testing protocols must adhere to international standards including USP, European Pharmacopoeia, and FAO/WHO Codex Alimentarius. Formulators should verify local regulatory requirements prior to market entry.
This product is intended for research, nutraceutical, and functional food applications. Not intended to diagnose, treat, cure, or prevent any disease.
69$/KG
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