69$/KG
liposomal Zinc Citrate 80% is a premium-grade dietary supplement ingredient delivering zinc citrate in an advanced liposomal delivery system. Zinc citrate (CAS 546-46-3 for anhydrous; CAS 5990-32-9 for dihydrate) is an organic zinc salt formed by the complete neutralization of citric acid with a high-purity zinc source, followed by precipitation and dehydration. The dihydrate form has the chemical formula Zn₃(C₆H₅O₇)₂·2H₂O and a molecular weight of 610.37 g/mol. It is a white, odorless, crystalline powder that is practically insoluble in water but soluble in dilute mineral acids. Zinc citrate contains approximately 31% elemental zinc, one of the highest zinc contents among organic zinc salts, and is widely used as a mineral source in functional foods, beverages, dietary supplements, and oral care products.
Zinc is an essential trace mineral present in all body tissues and fluids. As a component of over 200 enzymes, it is involved in more enzymatic reactions than any other mineral, affecting virtually all aspects of the immune system and playing essential roles in hormonal functions, skin and connective tissue metabolism, and sensory perception. However, conventional zinc salts can cause gastrointestinal discomfort at effective doses, and zinc absorption is subject to tight homeostatic regulation that limits fractional absorption as doses increase.
Zinc citrate already offers superior bioavailability compared to inorganic zinc salts, and studies have shown that chelated zinc forms such as zinc citrate are better absorbed and tolerated than zinc oxide. However, conventional zinc citrate formulations still face challenges related to gastrointestinal tolerability and the saturable nature of zinc absorption.
Liposomal encapsulation provides four critical advantages:
1. Enhanced Bioavailability and Absorption — Liposomal zinc citrate is a combination of zinc citrate encapsulated in liposomes to enhance absorption and reduce gastrointestinal irritation. Liposomal encapsulation is an advanced delivery method that increases zinc absorption, intracellular uptake, and bioavailability.
2. Reduced Gastrointestinal Irritation — The liposomal form is gentle on the stomach, highly absorbable, and bioavailable, making it suitable for individuals with sensitive stomachs. Liposomal encapsulation minimizes direct contact between zinc and the gastrointestinal mucosa, reducing the risk of nausea and cramping commonly associated with conventional zinc salts.
3. Enhanced Cellular Uptake — Liposomes fuse directly with intestinal cell membranes, facilitating efficient cellular delivery via lipid-mediated pathways. Encapsulating zinc citrate in liposomes can improve its absorption and cellular uptake, making it well-suited for applications where targeted delivery and controlled release are crucial.
4. Controlled Release — Liposomal formulations provide sustained release of zinc, maintaining consistent active levels for prolonged physiological support and reducing the risk of gastrointestinal discomfort associated with immediate-release zinc supplements.
High Purity — Standardized to ≥80% zinc citrate, with elemental zinc content of 30.0%–33.0% (USP/FCC).
Liposomal Enhancement — Phospholipid bilayer encapsulation enhances zinc absorption, intracellular uptake, and bioavailability while reducing gastrointestinal irritation.
Superior Bioavailability — Zinc citrate contains approximately 31% elemental zinc, one of the highest zinc contents among organic zinc salts, and offers better solubility and absorption than zinc oxide.
Immune Function Support — Zinc supports many aspects of innate and acquired immunity and has anti-inflammatory and antioxidant effects. Clinical trial data support the value of zinc in reducing the duration and severity of symptoms of the common cold when administered within 24 hours of onset.
Skin Health Benefits — Zinc citrate has beneficial effects for the health of hair and nails and helps heal skin wounds and skin conditions such as acne and eczema. Zinc compounds help suppress sebum secretion and reduce acne inflammation.
Gentle on the Stomach — The liposomal form is gentle on the stomach, highly absorbable, and bioavailable, making it suitable for individuals with sensitive stomachs.
Neutral Taste Profile — Zinc citrate has a neutral taste, unlike many other zinc salts, making it ideal for beverages and oral care applications.
Water-Dispersible — Suitable for capsules, tablets, powder drink mixes, functional beverages, and oral care formulations.
Batch Traceability — Complete COA, HPLC chromatogram, and identity data provided for each batch.
| Application | Recommended Usage | Notes |
|---|---|---|
| Capsules / Tablets | 15–30 mg elemental zinc per serving | 1 capsule daily with food; avoid taking with calcium or iron supplements |
| Functional Beverages | 5–15 mg per 250 mL | Water-dispersible; neutral taste |
| Powdered Drink Mixes | 15–30 mg per sachet | Blend with vitamin C for enhanced immune support |
| Immune Support Formulas | 25–40 mg per serving | Clinical trial protocols used 25–40 mg daily for acute infection or immune support |
| Skin Health Formulas | 15–30 mg per serving | Often combined with vitamin A, vitamin E, or biotin |
| Oral Care Products | 0.5%–2% in formulation | Antimicrobial and anti-inflammatory effects; reduces plaque and tartar formation |
Clinical studies and commercial products commonly recommend 15–30 mg of elemental zinc per day from zinc citrate. A representative commercial zinc citrate supplement provides 15 mg of elemental zinc per tablet with suggested use of one tablet daily with a meal. For immune support, clinical trial protocols have used 25–40 mg daily for acute infection or immune support. For common cold support, zinc lozenges providing 10 mg of zinc from zinc citrate per lozenge are available, with research supporting administration within 24 hours of symptom onset. The Tolerable Upper Intake Level (UL) for zinc is 40 mg per day for adults. Long-term intake of 25 mg or above may lead to anaemia and copper deficiency. Liposomal formulations may allow for more efficient utilization of lower doses due to enhanced bioavailability.
Stock Orders: 3–5 business days after payment confirmation.
Bulk / Custom Orders: 2–3 weeks, depending on quantity and customization requirements.
Shipping Methods: International Express (FedEx, DHL, UPS), air freight, and sea freight.
Coverage: Worldwide shipping, including remote areas.
Zinc Citrate Encyclopedia — Scientific Background
Zinc citrate (CAS 546-46-3 for anhydrous; CAS 5990-32-9 for dihydrate) is the zinc salt of citric acid, produced by complete neutralization of citric acid with a high-purity zinc source, followed by precipitation and dehydration. The dihydrate form has the chemical formula Zn₃(C₆H₅O₇)₂·2H₂O and a molecular weight of 610.37 g/mol. It is a white, odorless, crystalline powder that is practically insoluble in water but soluble in dilute mineral acids. Zinc citrate contains approximately 31% elemental zinc, one of the highest zinc contents among organic zinc salts, and is widely used as a mineral source in functional foods, beverages, dietary supplements, and oral care products.
| Property | Value |
|---|---|
| CAS No. | 546-46-3 (anhydrous); 5990-32-9 (dihydrate) |
| Molecular Formula | Zn₃(C₆H₅O₇)₂·2H₂O (dihydrate) |
| Molecular Weight | 610.37 g/mol (dihydrate) |
| EINECS | 208-901-2 |
| Appearance | White, odorless, crystalline powder |
| Solubility | Practically insoluble in water; soluble in dilute mineral acids |
| Elemental Zinc | ~31% |
| Purity (USP) | 98.0%–102.0% |
| Zinc Content (USP) | 30.0%–33.0% |
Zinc is an essential trace mineral present in all body tissues and fluids. As a component of over 200 enzymes, it is involved in more enzymatic reactions than any other mineral, affecting virtually all aspects of the immune system and playing essential roles in hormonal functions such as thyroid, insulin, growth, and sexual hormones.
Immune Function — Zinc supports many aspects of innate and acquired immunity and has anti-inflammatory and antioxidant effects. Clinical trial data support the value of zinc in reducing the duration and severity of symptoms of the common cold when administered within 24 hours of onset.
Skin Health — Zinc stabilizes and maintains the structural integrity of biological membranes and plays a pivotal role in skin and connective tissue metabolism and repair. Zinc citrate has beneficial effects for the health of hair and nails and helps heal skin wounds and skin conditions such as acne and eczema. Zinc compounds help suppress sebum secretion and reduce acne inflammation.
Protein Synthesis and Cell Growth — Zinc is essential for protein synthesis, cell growth, DNA formation, tissue repair, and immune system maintenance.
Enzymatic Cofactor — Zinc is a cofactor for over 200 enzymes involved in carbohydrate metabolism, protein synthesis, and nucleic acid metabolism.
Sensory Perception — Zinc supports sensory perception to smell, taste, and see.
Zinc affects virtually all aspects of the immune system. It is essential for the normal development and function of immune cells, including neutrophils, macrophages, and natural killer cells. Zinc deficiency results in impaired immune function, and supplementation has been shown to reduce the incidence and duration of infections.
Zinc plays a pivotal role in skin and connective tissue metabolism and repair. It is involved in collagen synthesis, keratinocyte proliferation and differentiation, and inflammatory regulation. Zinc compounds help suppress sebum secretion and reduce acne inflammation through modulation of inflammatory pathways and inhibition of 5α-reductase activity.
Zinc citrate is widely used in oral care products such as toothpastes, mouthwashes, and chewing gums due to its antimicrobial and anti-inflammatory effects and its ability to reduce or inhibit the formation of dental plaque and tartar. It helps reduce plaque, tartar, and bad breath.
Zinc absorption occurs primarily in the small intestine through carrier-mediated transport mechanisms. The amount of zinc absorbed is regulated by the body‘s zinc status and is subject to tight homeostatic regulation. Zinc absorption decreases as dietary or supplemental intake increases, and the fractional absorption of zinc declines at higher doses.
Conventional zinc citrate, while already offering superior bioavailability compared to inorganic zinc salts, still faces challenges related to gastrointestinal tolerability and the saturable nature of zinc absorption. liposomal encapsulation addresses these limitations through a phospholipid bilayer that protects zinc from premature interaction with dietary inhibitors, reduces gastrointestinal mucosal contact, and provides sustained release.
Liposomal encapsulation of zinc citrate provides a fundamentally different delivery mechanism from conventional forms. The phospholipid bilayer surrounds the zinc citrate complex, forming a protective shell that enhances absorption and reduces gastrointestinal irritation. This delivery system:
Enhances zinc absorption, intracellular uptake, and bioavailability
Reduces gastrointestinal irritation, making it gentle on the stomach
Provides controlled release for prolonged physiological support
Bypasses the saturable nature of carrier-mediated zinc transport
Liposomal zinc citrate is a combination of zinc citrate encapsulated in liposomes to enhance absorption and reduce gastrointestinal irritation. In nutritional formulations, it supports immune function, enzyme activity, skin and hair health, and normal metabolism of carbohydrates and proteins.
Clinical trial data support the value of zinc in reducing the duration and severity of symptoms of the common cold when administered within 24 hours of onset. Research has shown that zinc citrate is capable of preventing viral replication in the upper respiratory tract, making it acutely indicated during the common cold and other infections. Zinc lozenges containing zinc citrate are available and have been studied for cold symptom relief.
A randomized controlled trial is evaluating the efficacy of zinc citrate supplementation for young infants with clinical severe infection. This ongoing research highlights the importance of zinc in immune function during early development.
Zinc citrate is used in foods and supplements and has beneficial effects for the health of hair and nails and helps heal skin wounds and skin conditions such as acne and eczema. Zinc compounds help suppress sebum secretion and reduce acne inflammation.
Zinc citrate is generally well tolerated at commonly used doses. The Tolerable Upper Intake Level (UL) for zinc is 40 mg per day for adults. Long-term intake of 25 mg or above may lead to anaemia and copper deficiency. Common side effects of zinc supplementation may include gastrointestinal discomfort, nausea, and metallic taste.
Zinc citrate received GRAS status in the USA in 2009. In the European Union, zinc citrate is authorized as a food additive and is used as a source of zinc in food supplements. In China, zinc citrate is permitted as a food additive and nutritional fortificant for cereal products, beverages, and other foods. USP has established an official monograph for Zinc Citrate, specifying zinc content of 30.0%–33.0% and assay of 98.0%–102.0%. Testing protocols must adhere to international standards including USP, European Pharmacopoeia, and FAO/WHO Codex Alimentarius. Formulators should verify local regulatory requirements prior to market entry.
This product is intended for research, nutraceutical, and functional food applications. Not intended to diagnose, treat, cure, or prevent any disease.
69$/KG
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