99$/KG
89$/KG
Product Detailed Description
liposomal Magnesium L-Threonate 70% is a premium-grade dietary supplement ingredient delivering magnesium L-threonate (MgT) in an advanced liposomal delivery system. Magnesium L-threonate (CAS 778571-57-6) is a magnesium salt of L-threonic acid, a naturally occurring metabolite of vitamin C (L-ascorbic acid). The compound is chemically characterized by the molecular formula C₈H₁₄MgO₁₀ and a molecular weight of 294.5 g/mol.
Magnesium is an essential mineral involved in more than 600 biochemical reactions, contributing to normal Energy Metabolism, muscle function, nerve function, and psychological well-being. L-threonic acid serves not only as a carrier for magnesium but also as a bioactive metabolite. Magnesium L-threonate is unique among magnesium supplements in that it has been demonstrated to cross the blood-brain barrier and elevate brain magnesium levels, a property not observed with other magnesium forms such as magnesium oxide, citrate, or glycinate.
Magnesium L-threonate already offers superior bioavailability and targeted brain delivery compared to other magnesium forms. However, conventional MgT formulations still face absorption challenges related to its stability in the gastrointestinal environment and the need for efficient transport across the blood-brain barrier.
Liposomal encapsulation provides three critical advantages:
1. Digestive Protection — The phospholipid bilayer shields the magnesium-L-threonate complex from gastric acid degradation and interaction with dietary inhibitors, preserving its intact structure until reaching optimal absorption sites in the small intestine.
2. Enhanced Cellular Uptake — liposomes fuse directly with intestinal cell membranes, facilitating efficient cellular delivery via lipid-mediated pathways. This delivery mechanism complements the organic acid transport mechanisms utilized by MgT, supporting enhanced systemic absorption.
3. Synergistic Blood-Brain Barrier Delivery — Both the liposomal carrier and L-threonic acid facilitate crossing of the blood-brain barrier. This dual-route delivery system supports elevated brain magnesium concentrations, the primary mechanism by which MgT exerts its cognitive benefits.
| Field | Details |
|---|---|
| Product Name | Liposomal Magnesium L-Threonate 70% |
| CAS No. | 778571-57-6 |
| Active Ingredient | Magnesium L-Threonate (MgT) |
| Assay Method | EDTA complexometric titration or ICP-OES for elemental magnesium content; RP-HPLC with refractive index detector (RID) for L-threonic acid quantification; ICP-MS for heavy metal analysis; FTIR for chelation structure confirmation |
| Purity | ≥ 70% magnesium L-threonate; elemental magnesium ≥ 8.0% |
| Appearance / Color | White to off-white crystalline powder |
| Dosage Form | Liposomal powder, water-dispersible |
| Recommended Dosage | 1,000–2,000 mg per day; clinical trials have used 1,500–2,000 mg/day MgT |
| Application | Cognitive function, memory enhancement, synaptic plasticity, sleep quality, nervous system health, neuroprotection, mood support |
| Extract Source | Synthetic chelation (magnesium ion bound to L-threonic acid via proprietary chelation process) |
| Molecular Formula | C₈H₁₄MgO₁₀ |
| Molecular Weight | 294.5 g/mol |
| Lead Time | In stock: 3–5 business days; Bulk/custom orders: 2–3 weeks |
| Shipping Method | International Express (FedEx / DHL / UPS); air and sea freight available; worldwide shipping including remote areas |
| Storage | Cool, dry place away from direct sunlight and moisture; keep container tightly sealed. Shelf life: 24 months |
High Purity — Standardized to ≥70% magnesium L-threonate, ensuring consistent active content and ≥8.0% elemental magnesium.
Blood-Brain Barrier Penetration — Magnesium L-threonate is the only magnesium form clinically demonstrated to cross the blood-brain barrier and elevate brain magnesium levels.
Liposomal Enhancement — Phospholipid bilayer encapsulation protects the magnesium-chelate complex during digestive transit and enhances cellular delivery through lipid-mediated pathways.
Clinically Validated for Cognitive Function — Clinical studies have demonstrated that MgT supplementation improves cognitive function, sleep quality, and nervous system health.
Synaptic Plasticity Support — MgT elevates brain magnesium levels, supporting synaptic density and plasticity, the cellular basis of learning and memory.
Sleep and Recovery Support — Clinical trials have shown that MgT improves sleep depth, REM sleep, and cognitive function in athletic populations.
Water-Dispersible — Suitable for capsules, tablets, powder drink mixes, and functional beverages.
Batch Traceability — Complete COA, HPLC chromatogram, and identity data provided for each batch.
| Application | Recommended Usage | Notes |
|---|---|---|
| Capsules / Tablets | 500–1,000 mg per serving | 2–4 capsules daily with meals |
| Functional Beverages | 250–500 mg per 250 mL | Water-dispersible; suitable for RTD formats |
| Powdered Drink Mixes | 500–1,500 mg per sachet | Blend with L-theanine or phosphatidylserine for synergistic cognitive support |
| Cognitive Support Formulas | 1,000–2,000 mg per serving | Clinical trials used 1,500–2,000 mg/day |
| Sleep and Recovery Formulas | 500–1,000 mg per serving | Take in the evening to support sleep quality |
Clinical studies have evaluated magnesium L-threonate at doses ranging from 1,000 mg to 2,000 mg per day. A clinical trial evaluating MgT on sleep, recovery, and athletic performance in collegiate athletes used MgT supplementation to assess improvements in deep and REM sleep, heart rate variability, and brain recovery. Another clinical study is evaluating oral MgT supplementation for improving menopausal symptoms and quality of life among peri/post-menopausal women. For general cognitive and nervous system support, 1,000–2,000 mg daily is commonly used. Liposomal formulations may allow for more efficient utilization of lower doses due to enhanced bioavailability.
Stock Orders: 3–5 business days after payment confirmation.
Bulk / Custom Orders: 2–3 weeks, depending on quantity and customization requirements.
Shipping Methods: International Express (FedEx, DHL, UPS), air freight, and sea freight.
Coverage: Worldwide shipping, including remote areas.
Magnesium L-Threonate Encyclopedia — Scientific Background
Magnesium L-threonate (MgT) is a magnesium salt of L-threonic acid, a naturally occurring metabolite of vitamin C. It is chemically characterized by the molecular formula C₈H₁₄MgO₁₀ and a molecular weight of 294.5 g/mol. The compound is a white to off-white crystalline powder that is soluble in water. Magnesium L-threonate is distinguished from all other magnesium forms by its ability to cross the blood-brain barrier and directly elevate cerebrospinal fluid magnesium concentrations.
| Property | Value |
|---|---|
| CAS No. | 778571-57-6 |
| Molecular Formula | C₈H₁₄MgO₁₀ |
| Molecular Weight | 294.5 g/mol |
| IUPAC Name | Magnesium bis[(2R,3S)-2,3,4-trihydroxybutanoate] |
| Appearance | White to off-white crystalline powder |
| Solubility | Soluble in water |
| Elemental Magnesium | ~8.0% |
The most distinctive property of magnesium L-threonate is its ability to cross the blood-brain barrier and elevate brain magnesium levels. Its greatest feature is that it can smoothly cross the blood-brain barrier and directly act on the central nervous system. Unlike other magnesium forms that primarily affect peripheral tissues, MgT actively increases magnesium concentrations in the cerebrospinal fluid and brain tissue, supporting neurological function at the cellular level.
Magnesium plays a critical role in synaptic plasticity—the ability of synapses to strengthen or weaken over time, which is the cellular basis of learning and memory. By elevating brain magnesium levels, MgT supports synaptic density and plasticity. Research has shown that MgT improves cognitive functions, neuromuscular strength, and motor coordination in preclinical models. Behavioral tests have indicated that MgT significantly improves spatial learning, memory, and anxiety-related behaviors.
Magnesium L-threonate has demonstrated neuroprotective effects in various models. Studies have shown that MgT protects mitochondrial function and reduces ROS levels, inhibits AChE levels, and regulates anti-inflammatory pathways. Long-term MgT supplementation has been evaluated for its effects on neuroinflammation, demyelination, and blood-brain barrier integrity in neurological disorder models.
Magnesium L-threonate has been investigated for its effects on sleep quality and recovery. Clinical research in collegiate athletes has shown that MgT may improve deep and REM sleep, heart rate variability, and brain recovery. MgT crosses the blood-brain barrier and has been shown to improve sleep depth, REM sleep, and cognitive function.
Ongoing clinical research is evaluating the efficacy of oral MgT supplementation on improving menopausal symptoms and quality of life among peri/post-menopausal women. Unlike traditional magnesium supplements, MgT can cross the blood-brain barrier, making it uniquely capable of addressing neurological symptoms associated with menopause, such as pain and cognitive decline.
The combination of magnesium and L-threonic acid in a single chelated complex provides a unique dual-action benefit. Magnesium acts as a cofactor for more than 600 enzymatic reactions, including ATP synthesis, neurotransmitter regulation, and neuromuscular function. L-threonic acid, a metabolite of vitamin C, serves as a carrier that facilitates magnesium transport across the blood-brain barrier. This synergy supports efficient delivery of magnesium to the central nervous system, where it exerts its cognitive and neuroprotective effects.
liposomal encapsulation of magnesium L-threonate provides an additional layer of protection and delivery enhancement beyond the chelation itself. The phospholipid bilayer surrounds the magnesium-L-threonate complex, forming a shield that protects it from gastric acid and enzymatic degradation. This delivery system:
Protects MgT from gastric acid degradation and premature metabolism
Enhances intestinal absorption through lipid-mediated pathways
Complements the blood-brain barrier penetration property of L-threonic acid
Provides sustained release for prolonged cognitive and nervous system support
Liposomal magnesium L-threonate is supplied as a sunflower phospholipid liposomal powder. Quality control commonly focuses on active content, phospholipid carrier consistency, appearance, moisture, particle characteristics, microbial limits, heavy metals, and stability indicators.
Preclinical studies have demonstrated that magnesium L-threonate improves cognitive functions, neuromuscular strength, and motor coordination, with behavioral tests indicating significant improvements in spatial learning, memory, and anxiety-related behaviors.
A clinical trial evaluating the effects of MgT on sleep, recovery, and athletic performance in collegiate athletes is investigating improvements in deep and REM sleep, heart rate variability, and brain recovery. MgT crosses the blood-brain barrier and has been shown in non-athletic populations to improve sleep depth, REM sleep, and cognitive function.
An ongoing clinical trial is evaluating the efficacy of oral MgT supplementation on improving menopausal symptoms and quality of life among peri/post-menopausal women. The study specifically targets neurological symptoms associated with menopause, including pain and cognitive decline.
Magnesium L-threonate is generally well tolerated. Magnesium is an essential mineral, and MgT provides a bioavailable form that is efficiently utilized by the body. The L-threonic acid component is a metabolite of vitamin C, further supporting its safety profile. As with all magnesium supplements, excessive intake may cause gastrointestinal discomfort. The Tolerable Upper Intake Level (UL) for supplemental magnesium is 350 mg per day for adults. Liposomal encapsulation helps reduce gastrointestinal side effects through sustained release and improved absorption. Magnesium L-threonate is widely commercialized as a dietary supplement ingredient. Testing protocols must adhere to international standards including USP, European Pharmacopoeia, and FAO/WHO Codex Alimentarius. Formulators should verify local regulatory requirements prior to market entry.
This product is intended for research, nutraceutical, and functional food applications. Not intended to diagnose, treat, cure, or prevent any disease.
99$/KG
89$/KG
This website uses cookies to ensure you get the best experience on our website.
Español
Français
Deutsch
日本語
한국어
Phone
Comment
（0）