990$/KG
690$/KG
Product Detailed Description
liposomal PQQ 70% is a premium-grade dietary supplement ingredient delivering pyrroloquinoline quinone (PQQ) in an advanced liposomal delivery system. PQQ (CAS 72909-34-3), also known as methoxatin, is a water-soluble, vitamin-like redox-cycling orthoquinone initially isolated from cultures of methylotropic bacteria. It is a tricyclic ortho-quinone having two adjacent keto-groups at the 4 and 5 positions and three acidic carboxyl groups, with the molecular formula C₁₄H₆N₂O₈ and a molecular weight of 330.21 g/mol.
PQQ functions as a redox cofactor and an anionic redox-cycling protoquinone. Animal studies have demonstrated that insufficient dietary intake of PQQ can lead to notable deficits, including impaired growth and compromised reproductive outcomes. PQQ has been recognized for its neuroprotective effects in several in vitro and in vivo models of brain injury and disease, rendering it an attractive compound for treatment strategies targeting various neurological disorders.
Conventional PQQ faces formulation challenges including variable absorption and limited cellular delivery. While the disodium salt form of PQQ demonstrates improved solubility compared to the free acid, optimized delivery systems are required to maximize bioavailability and target tissue distribution.
Liposomal encapsulation provides three critical advantages:
1. Digestive Protection — The phospholipid bilayer shields PQQ from degradation during digestive transit, preserving its intact molecular structure until reaching optimal absorption sites. The incorporation of PQQ into liposomes and its interactions with lipids have been shown to enhance formulation stability for up to four weeks and allow sustained release for seven weeks.
2. Enhanced Cellular Uptake — Liposomes fuse directly with intestinal cell membranes, facilitating efficient cellular delivery and bypassing passive diffusion limitations. Small-size liposomes have excellent absorbability, and liposomal encapsulation enables extension of the optimum concentration range in which the distinctive function of PQQ is exhibited.
3. Sustained Release — Liposomal PQQ formulations exhibit biphasic release behavior, initially driven by the gradient of non-encapsulated PQQ followed by a sustained release of encapsulated PQQ. Optimized formulations with higher cholesterol content demonstrate gradual liberation profiles, with up to 90.3% of PQQ released over 7 weeks.
| Field | Details |
|---|---|
| Product Name | Liposomal PQQ 70% |
| CAS No. | 72909-34-3 |
| Active Ingredient | Pyrroloquinoline Quinone (PQQ) |
| Assay Method | HPLC-UV with C18 column; acid-labile PQQ extracted with neutral phosphate buffer; detection at 248 nm and 331 nm characteristic dual-peak profile; mobile phase tetrabutylammonium bromide-potassium dihydrogen phosphate mixed solution and acetonitrile gradient elution |
| Purity | ≥ 70% PQQ (HPLC); ≥ 98% assay available |
| Appearance / Color | Reddish-brown to dark red crystalline powder |
| Dosage Form | Liposomal powder, water-dispersible |
| Recommended Dosage | 10–20 mg per day; baseline intake level of 20 mg/day recommended; maximum suggested intake of 50 mg/day |
| Application | Mitochondrial biogenesis, cellular energy production, cognitive function, neuroprotection, antioxidant defense, inflammation modulation, metabolic support |
| Extract Source | Fermentation-derived (methylotrophic bacteria) or synthetic; liposomal carrier system with phospholipids |
| Molecular Formula | C₁₄H₆N₂O₈ |
| Molecular Weight | 330.21 g/mol |
| Lead Time | In stock: 3–5 business days; Bulk/custom orders: 2–3 weeks |
| Shipping Method | International Express (FedEx / DHL / UPS); air and sea freight available; worldwide shipping including remote areas |
| Storage | Cool, dry place away from direct sunlight and moisture; keep container tightly sealed. Shelf life: 24 months |
High Purity — Standardized to ≥70% PQQ by HPLC, ensuring consistent active content.
Liposomal Enhancement — Phospholipid bilayer encapsulation protects PQQ during digestive transit, enhances cellular uptake, and provides sustained release with biphasic kinetics.
Mitochondrial Biogenesis — PQQ stimulates mitochondrial biogenesis through activation of the SIRT1/PGC-1α signaling pathway, promoting new mitochondria formation and enhancing cellular energy capacity.
Neuroprotective Effects — PQQ reduces oxidative stress and inflammation via Nrf2 activation and NF-κB inhibition. It alleviates cognitive decline and neurological injury in preclinical studies and improves folate transport in cerebral folate deficiency.
Clinically Validated for Cognition — A randomized, double-blind, placebo-controlled trial in elderly individuals with mild cognitive impairment demonstrated that PQQ supplementation significantly elevated serum BDNF levels and improved cognitive function indices.
Antioxidant Defense — PQQ is a potent antioxidant that scavenges reactive oxygen species and protects mitochondria from oxidative damage. It blocks the formation of inducible nitric oxide synthase (iNOS), a major source of reactive nitrogen species.
Water-Soluble — Suitable for capsules, tablets, powder drink mixes, and functional beverages.
Batch Traceability — Complete COA, HPLC chromatogram, and identity data provided for each batch.
| Application | Recommended Usage | Notes |
|---|---|---|
| Capsules / Tablets | 10–20 mg per serving | 1–2 capsules daily with meals |
| Functional Beverages | 5–10 mg per 250 mL | Water-soluble; suitable for RTD formats |
| Powdered Drink Mixes | 10–20 mg per sachet | Blend with CoQ10 for synergistic Mitochondrial Support |
| Cognitive Support Formulas | 10–20 mg per serving | Clinical trials used 20 mg/day for cognitive benefits |
| Mitochondrial Health Formulas | 10–20 mg per serving | Often combined with NAD+ precursors or RESVERATROL |
Clinical studies and regulatory guidelines commonly recommend 10–20 mg of PQQ per day. The baseline intake level of PQQ is considered to be 20 mg/day, which is at least 250 times higher than the estimated background intake of PQQ naturally occurring in food. Mitsubishi Gas Chemical Company, in its FDA NDI notification, recommended a daily intake of 20 mg/day with a maximum suggested intake of 50 mg/day. PQQ disodium salt is intended to be used in foods at a maximum level of 20 mg PQQ disodium salt per serving. For chronic inflammatory conditions, 5–10 mg daily reduces circulating inflammatory cytokines; cognitive health optimization requires 10–20 mg daily; and metabolic support for mitochondrial function reaches optimal efficacy at approximately 20 mg daily. Liposomal formulations may allow for more efficient utilization of lower doses due to enhanced bioavailability.
Stock Orders: 3–5 business days after payment confirmation.
Bulk / Custom Orders: 2–3 weeks, depending on quantity and customization requirements.
Shipping Methods: International Express (FedEx, DHL, UPS), air freight, and sea freight.
Coverage: Worldwide shipping, including remote areas.
PQQ Encyclopedia — Scientific Background
Pyrroloquinoline quinone (PQQ), also known as methoxatin, is a water-soluble, vitamin-like redox-cycling orthoquinone initially isolated from cultures of methylotropic bacteria. It is an anionic, redox-cycling orthoquinone that functions as an enzyme cofactor belonging to the family of quinone cofactors (quinoproteins) naturally found in soil and food. PQQ was initially discovered as an essential cofactor for bacterial dehydrogenases and has since been reported to be involved in several biological processes important for mammalian growth and development.
| Property | Value |
|---|---|
| CAS No. | 72909-34-3 |
| Molecular Formula | C₁₄H₆N₂O₈ |
| Molecular Weight | 330.21 g/mol |
| IUPAC Name | 4,5-Dihydro-4,5-dioxo-1H-pyrrolo[2,3-f]quinoline-2,7,9-tricarboxylic acid |
| Appearance | Reddish-brown crystalline powder |
| Solubility | Water-soluble |
PQQ's most distinctive biological activity is its ability to stimulate mitochondrial biogenesis—the process by which cells increase their mitochondrial mass and energy-producing capacity. PQQ triggers mitochondrial biogenesis in vitro by activating peroxisome proliferator-activated receptor (PPAR)-γ coactivator (PGC)-1α. Mechanistic studies have demonstrated that PQQ stimulates mitochondrial biogenesis through cAMP response element-binding protein phosphorylation and increased PGC-1α expression. Research suggests that PQQ-inducible mitochondrial biogenesis can be attributed to activation of the SIRT1/PGC-1α signaling pathway. PQQ supplementation has been shown to upregulate the mRNA expression of PGC-1α and TFAM and augment mitochondrial DNA.
PQQ promotes mitochondrial biogenesis through PGC-1α/NRF-1 signaling. It may impact mitochondrial biogenesis and functions via PGC-1α, JNK, and mTOR pathways, and affects levels of inflammatory biomarkers and mitochondrial dysfunction. This mechanism underlies PQQ's capacity to enhance cellular Energy Metabolism and ATP production.
PQQ reduces oxidative stress and inflammation via Nrf2 activation and NF-κB inhibition. It has been shown to protect mitochondria from oxidative stress and block the formation of inducible nitric oxide synthase (iNOS), a major source of reactive nitrogen species that are damaging to brain cells. In retinal cell models, PQQ preserves ATP content and viability under mitochondrial stress.
PQQ has been recognized for its neuroprotective effects in several in vitro and in vivo models of brain injury and disease. More specifically, PQQ has been reported to enhance mitochondrial function and mitigate inflammatory and oxidative stress responses in the central nervous system through the activation of several signaling pathways. PQQ alleviates cognitive decline and neurological injury in preclinical studies and improves folate transport and reduces inflammation in cerebral folate deficiency.
PQQ downregulates inflammatory markers NLRP3 and Caspase 1 and reduces circulating inflammatory cytokines and C-reactive protein through mitochondrial-mediated pathways. For patients with chronic inflammatory conditions, PQQ at 5–10 mg daily reduces circulating inflammatory markers.
A parallel-group, randomized, placebo-controlled, double-blind study evaluated the impact of medium-term supplementation with dihydrogen and PQQ on mitochondrial biomarkers, brain metabolism, and cognition in 34 elderly individuals (mean age 71.9 ± 3.8 years) diagnosed with mild cognitive impairment. Participants received either a dihydrogen-PQQ mixture or placebo twice daily for a 6-week intervention period. Dihydrogen-PQQ resulted in a significant elevation in serum brain-derived neurotrophic factor (BDNF) levels at the six-week follow-up (P = 0.01). A significant interaction effect was observed for the Alzheimer's Disease Assessment Scale-Cognitive subscale (ADAS-Cog) scores in the orientation domain (P = 0.03), indicating the superiority of dihydrogen-PQQ over placebo in enhancing this cognitive aspect. Cerebral oxygenation saturation exhibited a significant increase following the administration of the dihydrogen-PQQ mixture, from 48.4 ± 7.2% at baseline to 52.8 ± 6.6% at 6-week post-administration (P = 0.005). Brain N-acetyl aspartate levels significantly increased at seven out of thirteen locations post-intervention (P ≤ 0.05).
Pyrroloquinoline quinone disodium salt has been proven to improve brain function and cognition in older adults (above 45 years). It is further shown that PQQ enhances language-related brain function in humans. PQQ is a food-based coenzyme with potent antioxidant properties that enhances various functions, which includes increasing the activity of NGF and its receptors.
A randomized clinical trial demonstrated functional improvement in glaucoma patients receiving a PQQ-containing combination. In retinal cell models, PQQ preserves ATP content and viability under mitochondrial stress. The resulting increase in NAD+ availability activates sirtuin-dependent programs that drive mitochondrial biogenesis.
Clinical evidence demonstrates statistically significant muscle strength improvement (p < 0.01) at 21.5 mg/day over 12 weeks.
liposomal encapsulation of PQQ provides a fundamentally different delivery mechanism from conventional forms. The phospholipid bilayer surrounds the PQQ molecule, forming a protective shell that enhances absorption and facilitates direct delivery to target tissues. This delivery system:
Protects PQQ from degradation during digestive transit
Enhances intestinal absorption through lipid-mediated pathways
Provides sustained release with biphasic kinetics
Supports efficient delivery to mitochondria and brain tissue
Published formulation studies demonstrate that PQQ-loaded liposomes exhibit biphasic release behavior, initially motivated by the gradient of non-encapsulated PQQ in the liposome, followed by a sustained release of the PQQ encapsulated in the liposomes. The release behavior was in accordance with the Weibull equation model, an empirical kinetic model used for initially fast and prolonged drug release profiles. Optimized formulations with higher cholesterol content demonstrated gradual liberation profiles with up to 90.3% of PQQ released over 7 weeks.
PQQ is a stable and water-soluble reddish-brown crystalline powder with mild hygroscopic properties that is an essential micronutrient for the human body, heart, and mind. PQQ disodium salt was approved as a new food ingredient by the FDA in 2008. Mitsubishi Gas Chemical Company submitted a 75-day premarket NDI notification to the FDA for its PQQ disodium salt, recommending a daily intake of 20 mg/day with a maximum suggested intake of 50 mg/day. PQQ has been reported to be toxic to the kidneys when administered via the intravenous or intraperitoneal route; however, no histopathological evidence of kidney toxicity has been observed when PQQ is administered via the oral route. Testing protocols must adhere to international standards including USP, European Pharmacopoeia, and FAO/WHO Codex Alimentarius. Formulators should verify local regulatory requirements prior to market entry.
This product is intended for research, nutraceutical, and functional food applications. Not intended to diagnose, treat, cure, or prevent any disease.
990$/KG
690$/KG
RELATED
This website uses cookies to ensure you get the best experience on our website.
Español
Français
Deutsch
日本語
한국어
Phone
Comment
（0）