89$/KG
liposomal L-Glutamine 80% is a premium-grade dietary supplement ingredient delivering L-glutamine in an advanced liposomal delivery system. L-Glutamine (CAS 56-85-9), also known as 2-aminoglutaramic acid or L-2-aminoglutaramidic acid, is the most abundant free amino acid in human blood and muscle tissue . It is chemically characterized by the molecular formula C₅H₁₀N₂O₃ and a molecular weight of 146.14 g/mol. It occurs as a white crystalline powder that is soluble in water and is a member of the glutamic acid family.
L-Glutamine is a non-essential amino acid under normal physiological conditions, but becomes conditionally essential during catabolic stress such as trauma, infection, starvation, or prolonged strenuous exercise . It is synthesized from glutamic acid and ammonia and is the principal carrier of nitrogen in the body . L-Glutamine is essential for the proliferation of intestinal epithelial cells and is a critical fuel source for rapidly dividing cells including enterocytes and lymphocytes.
Conventional L-glutamine presents significant formulation challenges. The compound is rapidly metabolized in the gastrointestinal tract and is taken up extensively by enterocytes and immune cells, limiting the fraction that reaches systemic circulation. During periods of stress, blood glutamine concentrations decrease substantially, often by 20–50%, indicating increased demand and depletion .
Liposomal encapsulation provides four critical advantages:
1. Enhanced Absorption and Bioavailability — Liposomal L-glutamine powder supplements feature a liposomal delivery system from non-GMO sunflower oil containing phosphatidylcholine, designed to enhance absorption and bioavailability . Encapsulation in lipid bilayers protects L-glutamine from premature metabolism in the gastrointestinal tract.
2. Protection from Rapid Metabolism — The phospholipid bilayer shields L-glutamine from enzymatic degradation, preserving its intact structure until reaching optimal absorption sites in the small intestine.
3. Enhanced Cellular Uptake — liposomes fuse directly with intestinal cell membranes, facilitating efficient cellular delivery via lipid-mediated pathways. This delivery mechanism complements the sodium-dependent amino acid transport pathways utilized by free L-glutamine.
4. Water-Dispersible Formulation — Liposomal L-glutamine powder offers excellent dispersibility in water, forming a uniform suspension suitable for functional beverages and liquid formulations .
High Purity — Standardized to ≥80% L-glutamine, with USP-grade assay of 98.5%–101.5% on dried basis available .
Liposomal Enhancement — Liposomal delivery matrix from non-GMO sunflower oil containing phosphatidylcholine enhances absorption and bioavailability .
Clinically Studied for Sickle Cell Disease — A randomized controlled study evaluated the safety and efficacy of L-glutamine in reducing the frequency of acute complications among patients with sickle cell disease .
Gut Health Support — L-glutamine is the primary fuel source for intestinal epithelial cells and supports the integrity of the intestinal lining.
Immune Function — L-glutamine is required for the proliferation of lymphocytes and supports immune cell function during periods of stress.
Muscle Recovery — L-glutamine is required for the biosynthesis of nucleotides and Glutathione, making it a candidate for supporting exercise recovery .
Water-Dispersible — Liposomal powder offers excellent dispersibility in water; suitable for capsules, tablets, powder drink mixes, and functional beverages.
Batch Traceability — Complete COA, HPLC chromatogram, and identity data provided for each batch.
Clinical studies and commercial products commonly recommend 5,000 mg of L-glutamine per serving daily for adults . A clinical trial in sickle cell disease patients used L-glutamine at a dose of 0.5 g/kg/day in two divided doses . A randomized controlled study evaluated the safety and efficacy of L-glutamine in reducing the frequency of acute complications among patients with sickle cell disease . For general gut health and immune support, 5,000 mg daily is commonly used. Commercial liposomal L-glutamine powder supplements typically recommend mixing one scoop (providing 5,000 mg L-glutamine) daily with 8 ounces of water or favorite beverage .
Stock Orders: 3–5 business days after payment confirmation.
Bulk / Custom Orders: 2–3 weeks, depending on quantity and customization requirements.
Shipping Methods: International Express (FedEx, DHL, UPS), air freight, and sea freight.
Coverage: Worldwide shipping, including remote areas.
L-Glutamine Encyclopedia — Scientific Background
L-Glutamine (CAS 56-85-9), also known as 2-aminoglutaramic acid or L-2-aminoglutaramidic acid, is the most abundant free amino acid in human blood and muscle tissue . It is chemically characterized by the molecular formula C₅H₁₀N₂O₃ and a molecular weight of 146.14 g/mol. It is a non-essential amino acid under normal physiological conditions, but becomes conditionally essential during catabolic stress. L-Glutamine is the principal carrier of nitrogen in the body and is an important energy source for many cells .
L-Glutamine is a non-essential amino acid present abundantly throughout the body and is involved in many metabolic processes . Key physiological roles include:
Nitrogen Transport — L-Glutamine is the principal carrier of nitrogen in the body, transporting ammonia safely between tissues .
Intestinal Health — L-Glutamine is the primary fuel source for intestinal epithelial cells and is essential for maintaining the integrity of the intestinal lining.
Immune Function — L-Glutamine is required for the proliferation of lymphocytes and supports immune cell function during periods of stress.
Neurotransmitter Precursor — L-Glutamine is required in the biosynthesis of neurotransmitters, nucleotides, nicotinamide-derived coenzymes, Glutathione, and hexosamines .
Muscle Recovery — L-Glutamine supports key mechanisms involved in muscle adaptation and recovery following exercise .
L-Glutamine is synthesized from glutamic acid and ammonia and serves as the principal carrier of nitrogen in the body . This nitrogen shuttle function is critical for safe transport of ammonia between tissues and for the synthesis of nucleotides, amino sugars, and other nitrogen-containing compounds.
L-Glutamine is the primary fuel source for rapidly dividing intestinal epithelial cells. It is essential for maintaining the integrity of the intestinal lining and supporting gut-associated immune function.
L-Glutamine is required for the biosynthesis of glutathione, the body’s master antioxidant, and supports the synthesis of nucleotides and nicotinamide-derived coenzymes . This makes L-glutamine an indirect contributor to cellular antioxidant defense.
L-Glutamine is required for the proliferation of lymphocytes and other immune cells. During periods of stress, infection, or trauma, glutamine demand increases substantially, and blood glutamine concentrations decrease, indicating its critical role in immune function .
Despite its essential physiological functions, native L-glutamine presents significant formulation challenges. The compound is rapidly metabolized in the gastrointestinal tract and is taken up extensively by enterocytes and immune cells. During periods of stress, such as clinical trauma, starvation, or prolonged strenuous exercise, the concentration of glutamine in the blood is decreased, often substantially .
liposomal encapsulation addresses these limitations through a phospholipid bilayer that protects L-glutamine during digestive transit and enhances intestinal absorption. Liposomal L-Glutamine powder supplements feature a liposomal delivery system designed to enhance absorption and bioavailability .
Liposomal encapsulation of L-glutamine provides a fundamentally different delivery mechanism from conventional forms. The phospholipid bilayer surrounds the L-glutamine molecule, forming a protective shell that enhances stability, absorption, and cellular uptake. This delivery system:
Protects L-glutamine from premature metabolism in the gastrointestinal tract
Enhances absorption through lipid-mediated pathways
Provides sustained release for prolonged amino acid availability
Enhances water dispersibility for use in aqueous formulations
Commercial liposomal L-glutamine supplements provide 5,000 mg of free-form L-glutamine per serving with a liposomal delivery matrix from non-GMO sunflower oil containing phosphatidylcholine . Capsule forms provide 1,000 mg of L-glutamine per serving (2 capsules) with the same liposomal delivery matrix .
A randomized controlled study evaluated the safety and efficacy of L-glutamine in reducing the frequency of acute complications among patients with sickle cell disease . The study was published in Annals of Hematology in 2024 and represents clinical investigation into the therapeutic applications of L-glutamine supplementation.
A systematic review and meta-analysis of clinical trials evaluated the effect of glutamine supplementation on athletic performance, body composition, and immune function. The study found that glutamine supplementation resulted in greater weight reduction and provided evidence for its role in supporting immune function during periods of stress .
A randomized, crossover, double-blind clinical study evaluated the safety of nutraceutical oral administration of L-glutamine in middle-aged and elderly individuals .
L-Glutamine is generally well tolerated at commonly used doses. The safety of oral L-glutamine has been evaluated in clinical studies in middle-aged and elderly individuals . During periods of stress, such as clinical trauma, starvation, or prolonged strenuous exercise, the concentration of glutamine in the blood is decreased, and supplementation may support restoration of normal levels .
L-Glutamine is widely commercialized as a dietary supplement ingredient and food additive. It is monographed in the USP, European Pharmacopoeia, and Japanese Pharmacopoeia (JP) . Testing protocols must adhere to international standards including USP, European Pharmacopoeia, and FAO/WHO Codex Alimentarius. Formulators should verify local regulatory requirements prior to market entry.
This product is intended for research, nutraceutical, and functional food applications. Not intended to diagnose, treat, cure, or prevent any disease.
89$/KG
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