59$/KG
Product Detailed Description
liposomal Ferric Pyrophosphate 80% is a premium-grade dietary supplement ingredient delivering ferric pyrophosphate (Fe₄(P₂O₇)₃) in an advanced liposomal delivery system. Ferric pyrophosphate is a water-insoluble ferric iron salt in which iron is complexed with pyrophosphate, offering several advantages over conventional ferrous iron salts: higher elemental iron content (24–30%), superior tolerability, no metallic aftertaste, and minimal impact on food color, taste, and texture. This makes it an ideal iron fortificant for food and beverage applications where sensory neutrality is critical.
Iron is an essential mineral required for hemoglobin synthesis, oxygen transport, electron transfer, and numerous enzymatic reactions. Ferric pyrophosphate is directly absorbed in the intestine, particularly by M cells in the duodenum. However, its water-insoluble nature limits absorption under normal physiological conditions. Liposomal encapsulation addresses this limitation by protecting iron through the gastric environment and releasing it primarily in the small intestine, while also enabling water dispersibility for use in instant beverages and aqueous systems.
Conventional ferric pyrophosphate, while well-tolerated and sensory-neutral, faces absorption challenges due to its poor water solubility. Ionic iron salts such as ferrous sulfate are more soluble but frequently cause gastrointestinal side effects including nausea, cramping, and constipation.
Liposomal encapsulation provides three critical advantages:
1. Gastric Protection — The phospholipid bilayer shields iron from gastric acid and prevents premature reactions with food components, preserving the iron-pyrophosphate complex until reaching optimal absorption sites in the small intestine.
2. Enhanced Dispersibility — The introduction of modified starch allows water-insoluble ferric pyrophosphate to disperse uniformly in cold water, enabling its use in instant beverages and other aqueous systems without sedimentation.
3. Improved Sensory Profile — Liposomal ferric iron offers significantly reduced metallic aftertaste, smooth and neutral mouthfeel, and high compatibility with flavored formulations, overcoming the limitations of traditional iron ingredients.
4. Clinically Validated Efficacy — A prospective randomized controlled trial in 192 children aged 2–12 years with iron-deficiency anemia demonstrated that liposomal iron (SunActive) achieved significantly higher hemoglobin, hematocrit, serum ferritin, and serum iron levels compared to conventional iron polymaltose complex after both 1 month and 6 months of therapy (P<0.001). The liposomal group also exhibited better growth-related anthropometric measurements and improved compliance rates.
| Field | Details |
|---|---|
| Product Name | Liposomal Ferric Pyrophosphate 80% |
| CAS No. | 10058-44-3 |
| Active Ingredient | Ferric Pyrophosphate (Fe₄(P₂O₇)₃) |
| Assay Method | HPLC with C18 reverse-phase column for pyrophosphate quantification; UV-Vis detection at 430 nm after desferrioxamine (DFO) chelation for iron determination; ICP-MS for elemental iron content and heavy metal analysis |
| Purity | ≥ 80% ferric pyrophosphate; elemental iron ≥ 80.0 mg/g |
| Appearance / Color | Light yellow to yellow powder |
| Dosage Form | Liposomal powder, water-dispersible |
| Recommended Dosage | 14–30 mg elemental iron per day for maintenance; 60–120 mg per day for iron deficiency; 1–2 capsules daily with food |
| Application | Iron deficiency anemia, hemoglobin formation, oxygen transport, food fortification, Energy Metabolism, cognitive function, pregnancy support |
| Extract Source | Synthetic (ferric iron complexed with pyrophosphate) |
| Molecular Formula | Fe₄(P₂O₇)₃ |
| Molecular Weight | 745.21 g/mol |
| Lead Time | In stock: 3–5 business days; Bulk/custom orders: 2–3 weeks |
| Shipping Method | International Express (FedEx / DHL / UPS); air and sea freight available; worldwide shipping including remote areas |
| Storage | Cool, dry place away from direct sunlight and moisture; keep container tightly sealed. Shelf life: 2 years when properly stored |
High Purity — Standardized to ≥80% ferric pyrophosphate with elemental iron content ≥80.0 mg/g, ensuring consistent active content.
Liposomal Enhancement — Phospholipid bilayer encapsulation achieves encapsulation efficiency exceeding 89%, with zeta potential of −39.47 mV and particle size of 1,296 nm for excellent colloidal stability.
Superior Gastrointestinal Tolerance — Ferric pyrophosphate is generally recognized as safe (GRAS) by the FDA for use as a nutrient supplement in conventional foods and infant formulas. Liposomal encapsulation further minimizes gastric irritation.
Clinically Validated — Randomized controlled trial in 192 children demonstrated superior efficacy in improving hemoglobin, ferritin, and serum iron levels compared to conventional iron supplements.
Sensory Neutral — No metallic aftertaste; minimal impact on food color, taste, and texture, making it ideal for food and beverage fortification.
Water-Dispersible — Disperses uniformly in cold water; suitable for capsules, tablets, powder drink mixes, and functional beverages.
Batch Traceability — Complete COA, HPLC chromatogram, and identity data provided for each batch.
| Application | Recommended Usage | Notes |
|---|---|---|
| Capsules / Tablets | 14–30 mg elemental iron per serving | Take with food for optimal tolerance |
| Functional Beverages | 10–20 mg per 250 mL | Water-dispersible; no metallic taste |
| Powdered Drink Mixes | 14–30 mg per sachet | Blend with vitamin C for enhanced absorption |
| Food Fortification | 5–15 mg per 100 g | Ideal for salt, rice, cheese, and dairy products |
| Pregnancy Support Formulas | 30–60 mg per serving | Liposomal iron is better tolerated and improves hemoglobin |
Clinical studies and commercial products commonly recommend 14–30 mg of elemental iron per day for maintenance in healthy adults and 60–120 mg per day for iron deficiency. A typical dosing regimen of 1–2 capsules daily provides approximately 14–30 mg elemental iron per serving. Ferric pyrophosphate can be taken with meals without the typical reduction in absorption seen with ionic iron forms, offering greater flexibility in dosing. Co-supplementation with vitamin C further enhances absorption. Iron status should be monitored through ferritin and transferrin saturation to guide dosing.
Stock Orders: 3–5 business days after payment confirmation.
Bulk / Custom Orders: 2–3 weeks, depending on quantity and customization requirements.
Shipping Methods: International Express (FedEx, DHL, UPS), air freight, and sea freight.
Coverage: Worldwide shipping, including remote areas.
Ferric Pyrophosphate Encyclopedia — Scientific Background
Ferric pyrophosphate (Fe₄(P₂O₇)₃) is a water-insoluble ferric iron salt in which iron is complexed with pyrophosphate. It is an iron coordination entity composed from Fe³⁺ cations and diphosphate anions in a 4:3 ratio. The compound is characterized by its high elemental iron content (24–30%), excellent sensory neutrality, and superior tolerability compared to conventional ferrous salts.
| Property | Value |
|---|---|
| CAS No. | 10058-44-3 |
| Molecular Formula | Fe₄(P₂O₇)₃ |
| Molecular Weight | 745.21 g/mol |
| Appearance | Light yellow to yellow powder |
| Solubility | Water-insoluble; soluble in aqueous acid |
| Elemental Iron | 24–30% |
Ferric pyrophosphate is a coordination compound in which ferric iron (Fe³⁺) is complexed with pyrophosphate anions (P₂O₇⁴⁻). The compound exists as a water-insoluble salt that dissolves under acidic conditions, such as those found in the stomach. This pH-dependent solubility is a key aspect of its function as an oral iron supplement—the compound is soluble in the acidic gastric environment and is released for absorption in the small intestine.
Ferric pyrophosphate is directly absorbed in the intestine, particularly by M cells in the duodenum. While its low solubility at neutral pH presents challenges for absorption, the iron that does become soluble can be taken up by intestinal enterocytes. In vitro studies using Caco-2 cells suggest that the uptake of iron from iron phosphates involves the Divalent Metal Transporter 1 (DMT1), with evidence also supporting the involvement of endocytic pathways.
liposomal encapsulation enhances this absorption by protecting the iron-pyrophosphate complex through the gastric environment and delivering it primarily to the small intestine—the key site of iron absorption. The liposomal delivery system utilizes endocytosis to enter cells directly, bypassing the DMT1 absorption ceiling and enabling efficient cellular delivery.
Iron is an essential trace mineral required for numerous physiological processes:
Hemoglobin Synthesis — Iron is the central atom in the heme group of hemoglobin, enabling oxygen transport from the lungs to tissues
Oxygen Transport — Iron-containing myoglobin facilitates oxygen storage and transport in muscle tissue
Electron Transfer — Iron-sulfur clusters and heme groups participate in mitochondrial electron transport chain reactions
Enzymatic Reactions — Iron is a cofactor for numerous enzymes involved in DNA synthesis, neurotransmitter production, and immune function
Energy Metabolism — Iron-containing cytochromes are essential for ATP production
A prospective randomized controlled trial evaluated 192 children aged 2–12 years diagnosed with iron-deficiency anemia. The patients were divided into two groups: 96 children received oral liposomal SunActive iron, and 96 children received conventional oral iron (iron polymaltose complex). After 1 month of oral iron therapy, the liposomal group exhibited higher hemoglobin, hematocrit, serum ferritin, and serum iron levels and greater transferrin saturation than the conventional iron group. After 6 months of therapy, hemoglobin level (P<0.001), iron profile (P<0.001), and growth-related anthropometric measurements were significantly higher in the liposomal group. The study concluded that orally administered liposomal SunActive iron exhibits better effects, reduced drug refusal rates, and improved compliance rates, thereby benefiting children's growth.
A comprehensive review published in Current Pharmaceutical Design (2026) summarized preclinical and clinical studies on ferric pyrophosphate, exploring its pathogenesis, chemistry, safety, and efficacy. The review noted that ferric pyrophosphate is favored due to its higher elemental iron content, superior bioavailability, tolerability, and minimal impact on food color, taste, and texture.
Liposomal encapsulation of ferric pyrophosphate provides a fundamentally different delivery mechanism from conventional iron forms. The phospholipid bilayer surrounds the iron-pyrophosphate complex, forming a shield that protects it from gastric acid and prevents premature reactions with food components.
An Indian patent (Application No. 202531003321) discloses a novel liposomal ferric pyrophosphate composition with encapsulation efficiency exceeding 89%. The manufacturing process involves optimized emulsification and spray drying techniques, ensuring consistent particle morphology and stability under varied storage conditions. The composition is remarkable for demonstrating better efficacy across populations, including pregnant women, children, and the elderly, with minimal side effects.
Characterization data confirms the successful production of liposomal ferric pyrophosphate:
Encapsulation efficiency: 89.01%, exceeding the minimum acceptable level of 85%
Elemental iron assay: 8.12%, within the acceptable range of 7.8% to 9.0% (USP Food Chemical Codex)
Zeta potential: −39.47 mV, exceeding the ±30 mV stability threshold
The high encapsulation efficiency suggests most iron particles are trapped within the liposomes, potentially leading to better absorption and fewer digestive issues compared to traditional iron supplements.
Ferric pyrophosphate is generally recognized as safe (GRAS) by the U.S. Food and Drug Administration for use as a nutrient supplement in conventional foods and in infant formulas. In 1994, the FDA included ferric pyrophosphate in its list of substances generally recognized as safe. The compound is widely used as a food fortificant due to its favorable sensory properties, high iron assay, and excellent stability. Testing protocols must adhere to international standards including USP, European Pharmacopoeia, and FAO/WHO Codex Alimentarius. Formulators should verify local regulatory requirements prior to market entry.
This product is intended for research, nutraceutical, and functional food applications. Not intended to diagnose, treat, cure, or prevent any disease.
59$/KG
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