69$/KG
Product Detailed Description
liposomal Calcium Citrate Malate 80% is a premium-grade dietary supplement ingredient delivering calcium citrate malate (CCM) in an advanced liposomal delivery system. Calcium citrate malate (CAS 142606-53-9) is a water-soluble calcium complex formed from calcium, citric acid, and malic acid in a 6:2:3 molar ratio, chemically characterized as Ca₆(C₆H₅O₇)₂(C₄H₄O₅)₃·6H₂O with a molecular weight of 1123.1 g/mol. It is a white, water-soluble powder with a pleasant fruity taste, making it suitable for both solid and liquid dosage forms.
Calcium is the most abundant mineral in the human body, with approximately 99% stored in bones and teeth as hydroxyapatite. The remaining 1% of "non-bone calcium" plays critical roles in muscle contraction, nerve impulse transmission, blood clotting, and hormone secretion. Calcium citrate malate is recognized by the European Food Safety Authority as "slightly more bioavailable" than other calcium sources and has been the subject of extensive clinical research in bone health.
Calcium citrate malate already offers superior bioavailability compared to calcium carbonate, with clinical studies demonstrating significantly better absorption in both rats and humans. However, even water-soluble calcium salts face absorption challenges related to saturable intestinal transport systems and interactions with dietary inhibitors.
Liposomal encapsulation provides four critical advantages:
1. Enhanced Stability and Protection — The phospholipid bilayer shields the calcium-citrate-malate complex from premature interaction with gastric contents and dietary inhibitors, preserving its intact structure until reaching optimal absorption sites in the small intestine.
2. Enhanced Cellular Uptake — liposomes fuse directly with intestinal cell membranes, facilitating efficient cellular delivery via lipid-mediated pathways. The citrate-malate component of CCM facilitates paracellular absorption, and liposomal encapsulation complements this mechanism for enhanced systemic uptake.
3. Superior Bioavailability — CCM has been shown to form significantly higher levels of soluble complexes at intestinal pH (pH 7.0) compared to other calcium salts, including calcium phosphate, which precipitates extensively under the same conditions. This solubility advantage translates directly into superior absorption.
4. Gentle on Digestion — Liposomal encapsulation minimizes direct contact between calcium and the gastrointestinal mucosa, reducing the risk of constipation and bloating frequently associated with conventional calcium supplements.
High Purity — Standardized to ≥80% calcium citrate malate, with elemental calcium content of 23.0%–24.2% (USP).
Superior Bioavailability — Clinical studies demonstrate that calcium from CCM is absorbed significantly better than from calcium carbonate or milk in both animal and human studies.
Water-Soluble Complex — CCM forms a soluble complex at intestinal pH (pH 7.0), unlike calcium phosphate which precipitates extensively under the same conditions.
Stomach-Acid Independent — CCM is absorbed equally well with or without food, making it ideal for individuals with low stomach acid, those taking proton pump inhibitors, and older adults.
Clinically Validated for Bone Health — A three-year, double-blind, placebo-controlled trial in 70 pairs of identical twins (mean age 10 ± 2 years) demonstrated that 1,000 mg/day of calcium citrate malate significantly increased bone mineral density.
Liposomal Enhancement — Phospholipid bilayer encapsulation protects the mineral complex during digestive transit and enhances cellular delivery through lipid-mediated pathways.
Water-Dispersible — Soluble in water with a pleasant fruity taste; suitable for capsules, tablets, powder drink mixes, and functional beverages.
Batch Traceability — Complete COA, HPLC chromatogram, and identity data provided for each batch.
| Application | Recommended Usage | Notes |
|---|---|---|
| Capsules / Tablets | 200–400 mg elemental calcium per serving | 2–3 capsules daily, with or without food |
| Functional Beverages | 100–250 mg per 250 mL | Water-soluble; suitable for RTD formats |
| Powdered Drink Mixes | 500–1,000 mg per sachet | Blend with vitamin D3 and K2 for synergistic bone support |
| Bone Health Formulas | 500–1,200 mg per serving | Often combined with vitamin D, magnesium, and vitamin K2 |
| Pediatric Bone Development | 500–1,000 mg per serving | Clinical trial used 1,000 mg/day in children aged 10 ± 2 years |
According to the International Osteoporosis Foundation, the recommended daily calcium intake for both women and men aged 19 to 50 years is 1,000 mg, increasing to 1,200 mg from age 51 in women and after 70 in men. For CCM specifically, clinical trials have used 1,000 mg/day of elemental calcium in children and adolescents for bone mineral density support. A common supplemental dose range is 500–600 mg/day of elemental calcium from CCM, which can be taken with or without food. The Tolerable Upper Intake Level (UL) for calcium is 2,000–2,500 mg per day for adults. Liposomal formulations may allow for more efficient utilization of lower doses due to enhanced bioavailability.
Stock Orders: 3–5 business days after payment confirmation.
Bulk / Custom Orders: 2–3 weeks, depending on quantity and customization requirements.
Shipping Methods: International Express (FedEx, DHL, UPS), air freight, and sea freight.
Coverage: Worldwide shipping, including remote areas.
Calcium Citrate Malate Encyclopedia — Scientific Background
Calcium citrate malate (CCM) is a water-soluble calcium supplement that is the calcium salt of citric acid and malic acid. It is a complex of calcium, citrate, and malate in a 6:2:3 molar ratio, with the chemical formula Ca₆(C₆H₅O₇)₂(C₄H₄O₅)₃·6H₂O and a molecular weight of 1123.1 g/mol. The compound is a white, odorless, water-soluble powder with a pleasant fruity taste, making it suitable for food fortification and beverage applications.
| Property | Value |
|---|---|
| CAS No. | 142606-53-9 (anhydrous); 159771-97-8 (hexahydrate) |
| Molecular Formula | Ca₆(C₆H₅O₇)₂(C₄H₄O₅)₃·6H₂O |
| Molecular Weight | 1123.1 g/mol |
| UNII | 4BBS3A53GJ |
| Appearance | White to off-white crystalline powder |
| Solubility | Water-soluble |
| Elemental Calcium | 23.0%–24.2% (USP) |
Intestinal calcium absorption occurs through two distinct mechanisms:
Transcellular Absorption — An active, energy-dependent process that takes place primarily in the duodenum. It is dependent on the concentration of calcium-binding proteins and is rapidly saturable. This pathway requires active vitamin D.
Paracellular Absorption — A passive, energy-independent process that occurs throughout the intestine. It is independent of calcium concentration in the gut lumen and is not rapidly saturable. This pathway is not vitamin D dependent.
Calcium citrate malate's superior bioavailability stems from its water-solubility and its method of dissolution. Calcium ions are absorbed directly into intestinal cells, and the citrate complex enters the body through paracellular absorption.
A key feature distinguishing CCM from other calcium salts is its solubility profile at intestinal pH. An in vitro study simulating gastrointestinal pH conditions evaluated six calcium salts (lactate, carbonate, citrate, gluconate, phosphate, and citrate malate). At pH 2.0 (gastric pH), 80–90% of all soluble calcium present was in the ionic form. However, when the pH was brought to 7.0 (intestinal pH), a unique solubility pattern for each calcium source was evident. Both calcium citrate and calcium citrate malate formed significantly higher levels of a soluble complex. By contrast, calcium phosphate precipitated extensively under the same conditions. This solubility advantage ensures that calcium from CCM remains available for absorption even in the neutral pH environment of the small intestine.
Clinical trials have demonstrated that calcium citrate malate supplementation significantly enhances bone mineral accretion. A three-year, double-blind, placebo-controlled trial of 70 pairs of identical twins (mean age 10 ± 2 years) evaluated the effect of calcium supplementation (1,000 mg/day of calcium citrate malate) on bone mineral density. The study demonstrated that calcium supplementation increases bone mineral density in children. A separate 18-month randomized controlled trial with 2-year follow-up in adolescent girls demonstrated that calcium supplementation enhanced bone mineral accrual, though the effect was short-lived.
A comparative absorption study tested a highly soluble form of calcium, a mixed calcium citrate-malate salt (CCM), against calcium carbonate and milk in both rats and humans. In two experiments in rats, calcium from CCM was absorbed at least as well as, if not better than, from calcium carbonate or milk. In two separate experiments in humans, calcium from CCM was absorbed significantly better than from calcium carbonate or milk. The study concluded that CCM exhibits excellent bioavailability and is a useful addition to the forms of calcium available for supplementation or food fortification.
| Property | Calcium Citrate Malate | Calcium Carbonate | Calcium Citrate |
|---|---|---|---|
| Elemental Calcium | 23–24% | ~40% | ~21% |
| Water Solubility | Soluble | Insoluble | Soluble |
| Food Dependency | Absorbed equally well with or without food | Should be taken with meals | Absorbed equally well with or without food |
| Stomach Acid Requirement | Not dependent | Requires gastric acid | Not dependent |
| Intestinal pH Solubility | Forms soluble complex | Precipitates | Forms soluble complex |
| Taste | Pleasant fruity taste | Chalky | Slightly chalky |
liposomal encapsulation of CCM provides a fundamentally different delivery mechanism from conventional forms. The phospholipid bilayer surrounds the calcium-citrate-malate complex, forming a protective shell that enhances absorption and enables lymphatic delivery. This delivery system:
Protects calcium from premature interaction with gastric contents and dietary inhibitors
Enhances intestinal absorption through both paracellular and lipid-mediated pathways
Provides sustained release with prolonged blood calcium elevation
Minimizes direct contact between calcium and the gastrointestinal mucosa
Calcium citrate malate is generally well tolerated. The most common side effects are gastrointestinal, including constipation and bloating, though these are less frequent with CCM than with calcium carbonate. The Tolerable Upper Intake Level (UL) for calcium is 2,000–2,500 mg per day for adults.
Calcium citrate malate is Generally Recognized As Safe (GRAS) in the United States and is approved for use in various food applications. The European Food Safety Authority (EFSA) has concluded that calcium from calcium citrate malate is slightly more bioavailable (8–15%) than calcium from some other calcium sources. In the European Union, CCM is authorized as a source of calcium for use in foods for particular nutritional uses and in foods for the general population, including food supplements. USP has established an official monograph for Calcium Citrate Malate (Catalog No. 1086425), specifying calcium content of 23.0%–24.2% and a minimum sum of citrate and malate of 73.0% on the dried basis. Testing protocols must adhere to international standards including USP, European Pharmacopoeia, and FAO/WHO Codex Alimentarius. Formulators should verify local regulatory requirements prior to market entry.
This product is intended for research, nutraceutical, and functional food applications. Not intended to diagnose, treat, cure, or prevent any disease.
69$/KG
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