259$/KG
199$/KG
Product Detailed Description
Liposomal Potassium Azeloycinate Diglycinate 70% is a premium-grade dietary supplement ingredient delivering potassium azeloyl diglycinate (PAD) in an advanced liposomal delivery system. Potassium azeloyl diglycinate (CAS 477773-67-4), also known as PAD, Azeloglicina, or potassium hydrogen heptylenedicarboxamidodiacetate, is the monopotassium salt of N,N'-(1,9-dioxo-1,9-nonanediyl)bis-glycine. It is chemically characterized by the molecular formula C₁₃H₂₁KN₂O₆ and a molecular weight of 340.41 g/mol. PAD is a water-soluble azelaic acid derivative formed by the neutralization of azelaic acid with glycine, typically supplied as a colorless to light yellow transparent liquid or a white to off-white powder.
PAD is a highly efficient modified form of azelaic acid, combining the oil control, anti-inflammatory, and whitening effects of azelaic acid with the moisturizing and soothing effects of glycine. Its excellent water solubility and low irritation make it a mild functional ingredient that can be used for sensitive skin, making it an "upgraded version" of azelaic acid. PAD has demonstrated sebostatic and whitening activities, inhibiting sebum secretion and melanin production while helping to even out skin tone and lighten spots.
Conventional PAD, while already offering superior water solubility and tolerability compared to azelaic acid, can be further enhanced through liposomal encapsulation. Liposomal delivery systems provide an additional protective layer that enhances skin penetration and facilitates efficient cellular delivery.
Liposomal encapsulation provides four critical advantages:
1. Enhanced Skin Penetration and Delivery — Liposomal encapsulation utilizes phospholipid-based carrier technology to enhance the percutaneous absorption of PAD. The liposomal bilayer mimics cell membrane structure, facilitating fusion with skin cells and efficient delivery of PAD to the target layers. This complements PAD's inherent water solubility and improves its bioavailability at the site of action.
2. Protection from Degradation — The phospholipid bilayer shields PAD from oxidative degradation and premature breakdown during storage and application, preserving its intact molecular structure until reaching target cells. PAD is known for strong stability and is not easy to oxidize, and liposomal encapsulation further extends this stability profile.
3. Reduced Irritation Potential — PAD is already recognized for its low irritation and suitability for sensitive skin. Liposomal encapsulation further minimizes direct contact between PAD and the skin surface, reducing the risk of the stinging sensation that can occur with azelaic acid and its derivatives, and improving tolerability for fragile or compromised skin.
4. Sustained Release for Prolonged Activity — Liposomal delivery provides a controlled-release profile that maintains steady levels of PAD at the target site, supporting prolonged sebum-regulating and skin-brightening activity rather than a sharp peak followed by rapid decline.
High Purity — Standardized to ≥70% potassium azeloyl diglycinate by HPLC, with ≥98% assay available for premium applications.
Liposomal Enhancement — Phospholipid bilayer encapsulation enhances skin penetration, protects from oxidative degradation, and provides sustained release for prolonged activity.
Superior Water Solubility — PAD is completely soluble in water, unlike azelaic acid, making it easy to formulate and apply in a wide range of product formats.
Sebum-Regulating and Anti-Acne — Inhibits sebum secretion, tightens pores, and effectively improves acne, blackheads, and pimples caused by excessive oil.
Mild Whitening and Spot Reduction — By inhibiting tyrosinase activity and melanin production, PAD helps to even out skin tone and lighten spots and acne marks.
Anti-Inflammatory and Soothing — Reduces acne inflammation and redness, suitable for soothing formulas for sensitive and acne-prone skin.
High Safety and Low Irritation — Suitable for sensitive skin, with excellent water solubility and low irritation making it a mild functional ingredient.
Water-Dispersible — Liposomal powder offers excellent dispersibility in aqueous systems; suitable for capsules, tablets, powder drink mixes, and functional beverages.
Batch Traceability — Complete COA, HPLC chromatogram, and identity data provided for each batch.
| Application | Recommended Usage | Notes |
|---|---|---|
| Capsules / Tablets | 100–300 mg per serving | 1–2 capsules daily with meals |
| Functional Beverages | 50–150 mg per 250 mL | Water-dispersible; suitable for RTD formats |
| Powdered Drink Mixes | 100–500 mg per sachet | Best absorbed when taken with food |
| Skin Brightening Formulas | 100–300 mg per serving | Often combined with vitamin C, niacinamide, or Glutathione |
| Sebum Regulation Formulas | 100–300 mg per serving | Often combined with zinc, vitamin B6, or green tea extract |
| Anti-Acne Formulas | 100–300 mg per serving | Often combined with zinc, niacinamide, or probiotics |
| Topical Formulations | 2–8% in formulation | Compatible with non-ionic emulsifiers; can be compounded with niacinamide, fruit acids, and hyaluronic acid |
Clinical studies and commercial products commonly recommend varying doses of PAD depending on the application. For topical formulations, the general recommended addition amount is 2–8%, with suggested adding amounts of 2–15% for drench and 2–10% for residual formulations. PAD powder is water-soluble, requires a lower dosage than azelaic acid, and has a strong anti-inflammatory effect. For oral supplementation, 100–500 mg per day is commonly used, depending on the intended application and formulation. Liposomal formulations may allow for more efficient utilization of lower doses due to enhanced bioavailability.
Stock Orders: 3–5 business days after payment confirmation.
Bulk / Custom Orders: 2–3 weeks, depending on quantity and customization requirements.
Shipping Methods: International Express (FedEx, DHL, UPS), air freight, and sea freight.
Coverage: Worldwide shipping, including remote areas.
Potassium Azeloycinate Diglycinate Encyclopedia — Scientific Background
Potassium azeloyl diglycinate (CAS 477773-67-4), also known as PAD, Azeloglicina, Corum 5150, or potassium hydrogen heptylenedicarboxamidodiacetate, is the monopotassium salt of N,N'-(1,9-dioxo-1,9-nonanediyl)bis-glycine. It is chemically characterized by the molecular formula C₁₃H₂₁KN₂O₆ and a molecular weight of 340.41 g/mol. PAD is a water-soluble azelaic acid derivative formed by the neutralization of azelaic acid with glycine, and is typically supplied as a colorless to light yellow transparent liquid or a white to off-white powder.
PAD represents a significant improvement over azelaic acid, the parent compound from which it is derived. Azelaic acid, a naturally occurring saturated dicarboxylic acid, is well established for its anti-acne, anti-rosacea, and skin-brightening properties. However, its clinical and cosmetic use is limited by poor water solubility, high melting point, large required dosages, susceptibility to discoloration, and poor compatibility with other formulation ingredients.
PAD addresses these limitations through the conjugation of azelaic acid with glycine. The resulting molecule is completely soluble in water, non-irritating to skin, and effective at low concentrations. The glycine moiety provides additional moisturizing and soothing benefits, making PAD suitable for sensitive skin types. PAD is described as a water-soluble diamine salt of azelaic acid that improves the technical properties of the formulation.
PAD's primary mechanism for acne management involves the inhibition of sebum secretion. PAD inhibits sebum production, tightens pores, and effectively improves acne, blackheads, and pimples caused by excessive oil. The compound also demonstrates anti-inflammatory and antibacterial properties, reducing acne inflammation and redness, and helping to soothe sensitive and acne-prone skin. PAD inhibits the growth of Cutibacterium acnes (formerly Propionibacterium acnes), the bacterium implicated in acne pathogenesis.
PAD achieves its skin-brightening effects through competitive inhibition of tyrosinase activity, the rate-limiting enzyme in melanin synthesis. By inhibiting tyrosinase and melanin production, PAD helps to even out skin tone and lighten spots, acne marks, and hyperpigmentation. The compound has demonstrated whitening activity in cosmetic formulations, with a concentration-dependent effect on melanin production.
PAD exhibits anti-inflammatory activity that reduces acne inflammation and redness, making it particularly suitable for soothing formulas for sensitive and acne-prone skin. This anti-inflammatory effect is attributed to the combined actions of the azelaic acid moiety and the glycine moiety, which together provide both sebum-regulating and calming benefits.
The diglycine structure of PAD provides humectant properties that improve skin hydration and help repair the skin barrier. PAD is used as a skin conditioning agent and humectant in cosmetics and personal care products, helping to improve moisturization, softness, and the feel of the skin barrier.
PAD has demonstrated sebostatic and whitening activities in clinical and cosmetic research. The compound is used in a wide range of skincare products for oil control, acne removal, and skin brightening. Its excellent water solubility and low irritation make it a preferred ingredient for sensitive skin formulations, and it can be compounded with a variety of active ingredients including niacinamide, fruit acids, and hyaluronic acid to enhance its efficacy.
PAD's whitening effects are achieved through tyrosinase inhibition and melanin production suppression, leading to visible improvements in skin tone and reductions in spots and hyperpigmentation. The compound is used in whitening essences, whitening masks, and skin-lightening waters to brighten skin tone, even skin tone, and lighten acne marks and spots.
PAD is recognized for its high safety profile and low irritation potential, making it suitable for sensitive skin. Unlike azelaic acid, which can cause transient stinging or burning upon application, PAD is non-irritating to skin and is effective at low concentrations. This favorable tolerability profile supports its use in formulations designed for fragile or sensitive skin, including hypoallergenic lotions and baby skincare products.
Potassium azeloyl diglycinate is generally recognized as safe for use in cosmetic and personal care products. The compound is listed in the FDA Global Substance Registration System with UNII code N02RVN6NYP and CAS Registry No. 477773-67-4. It is included in the MeSH Supplementary Concept Data with the note "has sebostatic and whitening activities".
Regulatory status varies by region:
United States — PAD is regulated as a cosmetic ingredient. It is listed in the FDA Substances Added to Food database and is available as a research chemical with ≥98% purity.
European Union — PAD is registered as a cosmetic ingredient under INCI name "Potassium Azeloyl Diglycinate" (CAS 477773-67-4, EINECS 686-756-8).
China — PAD is permitted as a cosmetic ingredient, and the Chinese national standard for its determination in cosmetics by HPLC has been established.
Global Standards — PAD is available with ISO9001, Halal, and Kosher certifications. The manufacturing process ensures heavy metal content ≤10 ppm and loss on drying ≤5.0%.
Testing protocols must adhere to international standards including USP, European Pharmacopoeia, and FAO/WHO Codex Alimentarius. Formulators should verify local regulatory requirements prior to market entry.
This product is intended for research, nutraceutical, and functional food applications. Not intended to diagnose, treat, cure, or prevent any disease.
259$/KG
199$/KG
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